Isolation of putative stem cells present in human adult olfactory mucosa

Tamara Tanos; Alberto Maria Saibene; Carlotta Pipolo; Paolo Battaglia; Giovanni Felisati; Alicia Rubio

doi:10.1371/journal.pone.0181151

Isolation of putative stem cells present in human adult olfactory mucosa

Tamara Tanos, Alberto Maria Saibene, Carlotta Pipolo, Paolo Battaglia, Giovanni Felisati, Alicia Rubio

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

The olfactory mucosa (OM) has the unique characteristic of performing an almost continuous and lifelong neurogenesis in response to external injuries, due to the presence of olfactory stem cells that guarantee the maintenance of the olfactory function. The easy accessibility of the OM in humans makes these stem cells feasible candidates for the development of regenerative therapies. In this report we present a detailed characterization of a patient-derived OM, together with a description of cell cultures obtained from the OM. In addition, we present a method for the enrichment and isolation of OM stem cells that might be used for future translational studies dealing with neuronal plasticity, neuro-regeneration or disease modeling.

Original language	English
Article number	e0181151
Journal	PLoS One
Volume	12
Issue number	7
DOIs	https://doi.org/10.1371/journal.pone.0181151
Publication status	Published - Jul 1 2017

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)

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AU - Felisati, Giovanni

AU - Rubio, Alicia

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AB - The olfactory mucosa (OM) has the unique characteristic of performing an almost continuous and lifelong neurogenesis in response to external injuries, due to the presence of olfactory stem cells that guarantee the maintenance of the olfactory function. The easy accessibility of the OM in humans makes these stem cells feasible candidates for the development of regenerative therapies. In this report we present a detailed characterization of a patient-derived OM, together with a description of cell cultures obtained from the OM. In addition, we present a method for the enrichment and isolation of OM stem cells that might be used for future translational studies dealing with neuronal plasticity, neuro-regeneration or disease modeling.

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Isolation of putative stem cells present in human adult olfactory mucosa

Abstract

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