TY - JOUR
T1 - Isolation of putative stem cells present in human adult olfactory mucosa
AU - Tanos, Tamara
AU - Saibene, Alberto Maria
AU - Pipolo, Carlotta
AU - Battaglia, Paolo
AU - Felisati, Giovanni
AU - Rubio, Alicia
PY - 2017/7/1
Y1 - 2017/7/1
N2 - The olfactory mucosa (OM) has the unique characteristic of performing an almost continuous and lifelong neurogenesis in response to external injuries, due to the presence of olfactory stem cells that guarantee the maintenance of the olfactory function. The easy accessibility of the OM in humans makes these stem cells feasible candidates for the development of regenerative therapies. In this report we present a detailed characterization of a patient-derived OM, together with a description of cell cultures obtained from the OM. In addition, we present a method for the enrichment and isolation of OM stem cells that might be used for future translational studies dealing with neuronal plasticity, neuro-regeneration or disease modeling.
AB - The olfactory mucosa (OM) has the unique characteristic of performing an almost continuous and lifelong neurogenesis in response to external injuries, due to the presence of olfactory stem cells that guarantee the maintenance of the olfactory function. The easy accessibility of the OM in humans makes these stem cells feasible candidates for the development of regenerative therapies. In this report we present a detailed characterization of a patient-derived OM, together with a description of cell cultures obtained from the OM. In addition, we present a method for the enrichment and isolation of OM stem cells that might be used for future translational studies dealing with neuronal plasticity, neuro-regeneration or disease modeling.
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U2 - 10.1371/journal.pone.0181151
DO - 10.1371/journal.pone.0181151
M3 - Article
C2 - 28719644
AN - SCOPUS:85024486966
VL - 12
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 7
M1 - e0181151
ER -