Isoniazid resistance in mycobacterium tuberculosis is a heterogeneous phenotype composed of overlapping mic distributions with different underlying resistance mechanisms

Arash Ghodousi, Elisa Tagliani, Eranga Karunaratne, Stefan Niemann, Jennifer Perera, Claudio U. Köser, Daniela Maria Cirillo

Research output: Contribution to journalArticle

Abstract

MIC testing using the Bactec mycobacteria growth indicator tube system 960 of 70 phylogenetically diverse, isoniazid-resistant clinical strains of Mycobacterium tuberculosis revealed a complex pattern of overlapping MIC distributions. Whole-genome sequencing explained most of the levels of resistance observed. The MIC distribution of strains with only inhA promoter mutations was split by the current concentration endorsed by the Clinical and Laboratory Standards Institute to detect low-level resistance to isoniazid and is, consequently, likely not optimally set.

Original languageEnglish
Article numbere00092-19
JournalAntimicrobial Agents and Chemotherapy
Volume63
Issue number7
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • Isoniazid resistance
  • MGIT 960
  • MIC
  • Mycobacterium tuberculosis
  • Whole-genome sequencing

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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