Isoprostanes and oxidative stress in off-pump and on-pump coronary bypass surgery

Viviana Cavalca, Erminio Sisillo, Fabrizio Veglia, Elena Tremoli, Giuliana Cighetti, Luca Salvi, Alessandra Sola, Luciana Mussoni, Paolo Biglioli, Giancarlo Folco, Angelo Sala, Alessandro Parolari

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Background. Conventional on-pump coronary artery bypass grafting (CABG) is associated with a systemic inflammatory response and by an increased production of reactive oxygen species, whereas off-pump coronary artery bypass grafting (OPCAB) is thought to be accompanied by less oxidative stress. Urinary isoprostane iPF-III is a new marker reflecting oxidative stress; it has emerged as the most reliable marker of oxidative stress status in vivo. This study was designed to ascertain whether OPCAB compared with CABG represents a surgical strategy that avoids oxidative stress. To this end urinary isoprostanes and other established oxidative stress markers were measured during the first 24 hours after CABG and OPCAB. Methods. Fifty low-risk coronary patients were randomly assigned to CABG or OPCAB. Urinary isoprostane iPF -III levels, plasma levels of free malondialdehyde, and total antioxidant status were measured before, during, and up to 24 hours after surgery. Results. In OPCAB iPF-III excretion remained unchanged throughout the study. As expected, in CABG iPF-III levels significantly increased during surgery and returned at baseline 24 hours later. Free malondialdehyde behaved similarly, with no change in OPCAB and sharp increases during CABG. Conversely, total antioxidant status showed a sharp drop during CABG, followed by a slow recovery, whereas a significantly lower drop occurred in OPCAB. Conclusions. In this randomized study in low-risk coronary patients, OPCAB revealed less perioperative oxidative stress, as reflected by lack of excretion of iPF-III in urine, by lack of increase of plasma free malondialdehyde, and by lower decreases in plasma total antioxidant status.

Original languageEnglish
Pages (from-to)562-567
Number of pages6
JournalAnnals of Thoracic Surgery
Volume81
Issue number2
DOIs
Publication statusPublished - Feb 2006

Fingerprint

Isoprostanes
Coronary Artery Bypass
Oxidative Stress
Off-Pump Coronary Artery Bypass
Malondialdehyde
Antioxidants

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Isoprostanes and oxidative stress in off-pump and on-pump coronary bypass surgery. / Cavalca, Viviana; Sisillo, Erminio; Veglia, Fabrizio; Tremoli, Elena; Cighetti, Giuliana; Salvi, Luca; Sola, Alessandra; Mussoni, Luciana; Biglioli, Paolo; Folco, Giancarlo; Sala, Angelo; Parolari, Alessandro.

In: Annals of Thoracic Surgery, Vol. 81, No. 2, 02.2006, p. 562-567.

Research output: Contribution to journalArticle

Cavalca, Viviana ; Sisillo, Erminio ; Veglia, Fabrizio ; Tremoli, Elena ; Cighetti, Giuliana ; Salvi, Luca ; Sola, Alessandra ; Mussoni, Luciana ; Biglioli, Paolo ; Folco, Giancarlo ; Sala, Angelo ; Parolari, Alessandro. / Isoprostanes and oxidative stress in off-pump and on-pump coronary bypass surgery. In: Annals of Thoracic Surgery. 2006 ; Vol. 81, No. 2. pp. 562-567.
@article{b5f3774458d345d98b779798ea6dd220,
title = "Isoprostanes and oxidative stress in off-pump and on-pump coronary bypass surgery",
abstract = "Background. Conventional on-pump coronary artery bypass grafting (CABG) is associated with a systemic inflammatory response and by an increased production of reactive oxygen species, whereas off-pump coronary artery bypass grafting (OPCAB) is thought to be accompanied by less oxidative stress. Urinary isoprostane iPF2α-III is a new marker reflecting oxidative stress; it has emerged as the most reliable marker of oxidative stress status in vivo. This study was designed to ascertain whether OPCAB compared with CABG represents a surgical strategy that avoids oxidative stress. To this end urinary isoprostanes and other established oxidative stress markers were measured during the first 24 hours after CABG and OPCAB. Methods. Fifty low-risk coronary patients were randomly assigned to CABG or OPCAB. Urinary isoprostane iPF 2α-III levels, plasma levels of free malondialdehyde, and total antioxidant status were measured before, during, and up to 24 hours after surgery. Results. In OPCAB iPF2α-III excretion remained unchanged throughout the study. As expected, in CABG iPF2α-III levels significantly increased during surgery and returned at baseline 24 hours later. Free malondialdehyde behaved similarly, with no change in OPCAB and sharp increases during CABG. Conversely, total antioxidant status showed a sharp drop during CABG, followed by a slow recovery, whereas a significantly lower drop occurred in OPCAB. Conclusions. In this randomized study in low-risk coronary patients, OPCAB revealed less perioperative oxidative stress, as reflected by lack of excretion of iPF2α-III in urine, by lack of increase of plasma free malondialdehyde, and by lower decreases in plasma total antioxidant status.",
author = "Viviana Cavalca and Erminio Sisillo and Fabrizio Veglia and Elena Tremoli and Giuliana Cighetti and Luca Salvi and Alessandra Sola and Luciana Mussoni and Paolo Biglioli and Giancarlo Folco and Angelo Sala and Alessandro Parolari",
year = "2006",
month = "2",
doi = "10.1016/j.athoracsur.2005.08.019",
language = "English",
volume = "81",
pages = "562--567",
journal = "Annals of Thoracic Surgery",
issn = "0003-4975",
publisher = "The Society of Thoracic Surgeons. Published by Elsevier Inc",
number = "2",

}

TY - JOUR

T1 - Isoprostanes and oxidative stress in off-pump and on-pump coronary bypass surgery

AU - Cavalca, Viviana

AU - Sisillo, Erminio

AU - Veglia, Fabrizio

AU - Tremoli, Elena

AU - Cighetti, Giuliana

AU - Salvi, Luca

AU - Sola, Alessandra

AU - Mussoni, Luciana

AU - Biglioli, Paolo

AU - Folco, Giancarlo

AU - Sala, Angelo

AU - Parolari, Alessandro

PY - 2006/2

Y1 - 2006/2

N2 - Background. Conventional on-pump coronary artery bypass grafting (CABG) is associated with a systemic inflammatory response and by an increased production of reactive oxygen species, whereas off-pump coronary artery bypass grafting (OPCAB) is thought to be accompanied by less oxidative stress. Urinary isoprostane iPF2α-III is a new marker reflecting oxidative stress; it has emerged as the most reliable marker of oxidative stress status in vivo. This study was designed to ascertain whether OPCAB compared with CABG represents a surgical strategy that avoids oxidative stress. To this end urinary isoprostanes and other established oxidative stress markers were measured during the first 24 hours after CABG and OPCAB. Methods. Fifty low-risk coronary patients were randomly assigned to CABG or OPCAB. Urinary isoprostane iPF 2α-III levels, plasma levels of free malondialdehyde, and total antioxidant status were measured before, during, and up to 24 hours after surgery. Results. In OPCAB iPF2α-III excretion remained unchanged throughout the study. As expected, in CABG iPF2α-III levels significantly increased during surgery and returned at baseline 24 hours later. Free malondialdehyde behaved similarly, with no change in OPCAB and sharp increases during CABG. Conversely, total antioxidant status showed a sharp drop during CABG, followed by a slow recovery, whereas a significantly lower drop occurred in OPCAB. Conclusions. In this randomized study in low-risk coronary patients, OPCAB revealed less perioperative oxidative stress, as reflected by lack of excretion of iPF2α-III in urine, by lack of increase of plasma free malondialdehyde, and by lower decreases in plasma total antioxidant status.

AB - Background. Conventional on-pump coronary artery bypass grafting (CABG) is associated with a systemic inflammatory response and by an increased production of reactive oxygen species, whereas off-pump coronary artery bypass grafting (OPCAB) is thought to be accompanied by less oxidative stress. Urinary isoprostane iPF2α-III is a new marker reflecting oxidative stress; it has emerged as the most reliable marker of oxidative stress status in vivo. This study was designed to ascertain whether OPCAB compared with CABG represents a surgical strategy that avoids oxidative stress. To this end urinary isoprostanes and other established oxidative stress markers were measured during the first 24 hours after CABG and OPCAB. Methods. Fifty low-risk coronary patients were randomly assigned to CABG or OPCAB. Urinary isoprostane iPF 2α-III levels, plasma levels of free malondialdehyde, and total antioxidant status were measured before, during, and up to 24 hours after surgery. Results. In OPCAB iPF2α-III excretion remained unchanged throughout the study. As expected, in CABG iPF2α-III levels significantly increased during surgery and returned at baseline 24 hours later. Free malondialdehyde behaved similarly, with no change in OPCAB and sharp increases during CABG. Conversely, total antioxidant status showed a sharp drop during CABG, followed by a slow recovery, whereas a significantly lower drop occurred in OPCAB. Conclusions. In this randomized study in low-risk coronary patients, OPCAB revealed less perioperative oxidative stress, as reflected by lack of excretion of iPF2α-III in urine, by lack of increase of plasma free malondialdehyde, and by lower decreases in plasma total antioxidant status.

UR - http://www.scopus.com/inward/record.url?scp=31044453308&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=31044453308&partnerID=8YFLogxK

U2 - 10.1016/j.athoracsur.2005.08.019

DO - 10.1016/j.athoracsur.2005.08.019

M3 - Article

VL - 81

SP - 562

EP - 567

JO - Annals of Thoracic Surgery

JF - Annals of Thoracic Surgery

SN - 0003-4975

IS - 2

ER -