Abstract
Cerebrospinal fluid (CSF) and serum samples from patients with multiple sclerosis and other neurological diseases were examined by capillary isotachophoresis (ITP). The percentage and the rate of synthesis of CSF IgG which migrated slowly with ITP were calculated. CSF specimens of most patients with multiple sclerosis contained increased percentages of slowly migrating IgG (slow IgG), corresponding to IgG oligoclonal bands in the "high-alkaline" region on isoelectric focusing. The patients with multiple sclerosis were found to have increased intrathecal synthesis of slow IgG, which correlated closely with the rate of intrathecal CNS IgG synthesis calculated by Tourtellotte's formula.
| Original language | English |
|---|---|
| Pages (from-to) | 55-60 |
| Number of pages | 6 |
| Journal | Journal of Neurology |
| Volume | 229 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Mar 1983 |
Fingerprint
Keywords
- Cerebrospinal fluid
- IgG
- Isotachophoresis
- Multiple sclerosis
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
Cite this
Isotachophoresis evaluation of synthesis of intrathecal IgG subfractions in multiple sclerosis. / Zaffaroni, M.; Caputo, D.; Cazzullo, C. L.
In: Journal of Neurology, Vol. 229, No. 1, 03.1983, p. 55-60.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Isotachophoresis evaluation of synthesis of intrathecal IgG subfractions in multiple sclerosis
AU - Zaffaroni, M.
AU - Caputo, D.
AU - Cazzullo, C. L.
PY - 1983/3
Y1 - 1983/3
N2 - Cerebrospinal fluid (CSF) and serum samples from patients with multiple sclerosis and other neurological diseases were examined by capillary isotachophoresis (ITP). The percentage and the rate of synthesis of CSF IgG which migrated slowly with ITP were calculated. CSF specimens of most patients with multiple sclerosis contained increased percentages of slowly migrating IgG (slow IgG), corresponding to IgG oligoclonal bands in the "high-alkaline" region on isoelectric focusing. The patients with multiple sclerosis were found to have increased intrathecal synthesis of slow IgG, which correlated closely with the rate of intrathecal CNS IgG synthesis calculated by Tourtellotte's formula.
AB - Cerebrospinal fluid (CSF) and serum samples from patients with multiple sclerosis and other neurological diseases were examined by capillary isotachophoresis (ITP). The percentage and the rate of synthesis of CSF IgG which migrated slowly with ITP were calculated. CSF specimens of most patients with multiple sclerosis contained increased percentages of slowly migrating IgG (slow IgG), corresponding to IgG oligoclonal bands in the "high-alkaline" region on isoelectric focusing. The patients with multiple sclerosis were found to have increased intrathecal synthesis of slow IgG, which correlated closely with the rate of intrathecal CNS IgG synthesis calculated by Tourtellotte's formula.
KW - Cerebrospinal fluid
KW - IgG
KW - Isotachophoresis
KW - Multiple sclerosis
UR - http://www.scopus.com/inward/record.url?scp=0020692060&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020692060&partnerID=8YFLogxK
U2 - 10.1007/BF00313496
DO - 10.1007/BF00313496
M3 - Article
C2 - 6189977
AN - SCOPUS:0020692060
VL - 229
SP - 55
EP - 60
JO - Journal of Neurology
JF - Journal of Neurology
SN - 0340-5354
IS - 1
ER -