Isotachophoresis evaluation of synthesis of intrathecal IgG subfractions in multiple sclerosis

M. Zaffaroni, D. Caputo, C. L. Cazzullo

Research output: Contribution to journal › Article

5 Citations (Scopus)

Abstract

Cerebrospinal fluid (CSF) and serum samples from patients with multiple sclerosis and other neurological diseases were examined by capillary isotachophoresis (ITP). The percentage and the rate of synthesis of CSF IgG which migrated slowly with ITP were calculated. CSF specimens of most patients with multiple sclerosis contained increased percentages of slowly migrating IgG (slow IgG), corresponding to IgG oligoclonal bands in the "high-alkaline" region on isoelectric focusing. The patients with multiple sclerosis were found to have increased intrathecal synthesis of slow IgG, which correlated closely with the rate of intrathecal CNS IgG synthesis calculated by Tourtellotte's formula.

Original languageEnglish
Pages (from-to)55-60
Number of pages6
JournalJournal of Neurology
Volume229
Issue number1
DOIs
Publication statusPublished - Mar 1983

Fingerprint

Isotachophoresis
Multiple Sclerosis
Immunoglobulin G
Cerebrospinal Fluid
Oligoclonal Bands
Isoelectric Focusing
Serum

Keywords

  • Cerebrospinal fluid
  • IgG
  • Isotachophoresis
  • Multiple sclerosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Isotachophoresis evaluation of synthesis of intrathecal IgG subfractions in multiple sclerosis. / Zaffaroni, M.; Caputo, D.; Cazzullo, C. L.

In: Journal of Neurology, Vol. 229, No. 1, 03.1983, p. 55-60.

Research output: Contribution to journal › Article

Zaffaroni, M, Caputo, D & Cazzullo, CL 1983, 'Isotachophoresis evaluation of synthesis of intrathecal IgG subfractions in multiple sclerosis', Journal of Neurology, vol. 229, no. 1, pp. 55-60. https://doi.org/10.1007/BF00313496
Zaffaroni M, Caputo D, Cazzullo CL. Isotachophoresis evaluation of synthesis of intrathecal IgG subfractions in multiple sclerosis. Journal of Neurology. 1983 Mar;229(1):55-60. https://doi.org/10.1007/BF00313496
Zaffaroni, M. ; Caputo, D. ; Cazzullo, C. L. / Isotachophoresis evaluation of synthesis of intrathecal IgG subfractions in multiple sclerosis. In: Journal of Neurology. 1983 ; Vol. 229, No. 1. pp. 55-60.
@article{23848d3a8d60421d9d47de26090d2644,
title = "Isotachophoresis evaluation of synthesis of intrathecal IgG subfractions in multiple sclerosis",
abstract = "Cerebrospinal fluid (CSF) and serum samples from patients with multiple sclerosis and other neurological diseases were examined by capillary isotachophoresis (ITP). The percentage and the rate of synthesis of CSF IgG which migrated slowly with ITP were calculated. CSF specimens of most patients with multiple sclerosis contained increased percentages of slowly migrating IgG (slow IgG), corresponding to IgG oligoclonal bands in the {"}high-alkaline{"} region on isoelectric focusing. The patients with multiple sclerosis were found to have increased intrathecal synthesis of slow IgG, which correlated closely with the rate of intrathecal CNS IgG synthesis calculated by Tourtellotte's formula.",
keywords = "Cerebrospinal fluid, IgG, Isotachophoresis, Multiple sclerosis",
author = "M. Zaffaroni and D. Caputo and Cazzullo, {C. L.}",
year = "1983",
month = "3",
doi = "10.1007/BF00313496",
language = "English",
volume = "229",
pages = "55--60",
journal = "Journal of Neurology",
issn = "0340-5354",
publisher = "Dr. Dietrich Steinkopff Verlag GmbH and Co. KG",
number = "1",

}

TY - JOUR

T1 - Isotachophoresis evaluation of synthesis of intrathecal IgG subfractions in multiple sclerosis

AU - Zaffaroni, M.

AU - Caputo, D.

AU - Cazzullo, C. L.

PY - 1983/3

Y1 - 1983/3

N2 - Cerebrospinal fluid (CSF) and serum samples from patients with multiple sclerosis and other neurological diseases were examined by capillary isotachophoresis (ITP). The percentage and the rate of synthesis of CSF IgG which migrated slowly with ITP were calculated. CSF specimens of most patients with multiple sclerosis contained increased percentages of slowly migrating IgG (slow IgG), corresponding to IgG oligoclonal bands in the "high-alkaline" region on isoelectric focusing. The patients with multiple sclerosis were found to have increased intrathecal synthesis of slow IgG, which correlated closely with the rate of intrathecal CNS IgG synthesis calculated by Tourtellotte's formula.

AB - Cerebrospinal fluid (CSF) and serum samples from patients with multiple sclerosis and other neurological diseases were examined by capillary isotachophoresis (ITP). The percentage and the rate of synthesis of CSF IgG which migrated slowly with ITP were calculated. CSF specimens of most patients with multiple sclerosis contained increased percentages of slowly migrating IgG (slow IgG), corresponding to IgG oligoclonal bands in the "high-alkaline" region on isoelectric focusing. The patients with multiple sclerosis were found to have increased intrathecal synthesis of slow IgG, which correlated closely with the rate of intrathecal CNS IgG synthesis calculated by Tourtellotte's formula.

KW - Cerebrospinal fluid

KW - IgG

KW - Isotachophoresis

KW - Multiple sclerosis

UR - http://www.scopus.com/inward/record.url?scp=0020692060&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020692060&partnerID=8YFLogxK

U2 - 10.1007/BF00313496

DO - 10.1007/BF00313496

M3 - Article

VL - 229

SP - 55

EP - 60

JO - Journal of Neurology

JF - Journal of Neurology

SN - 0340-5354

IS - 1

ER -

Access to Document