Abstract
Objective. To correlate the clinical course of the disease with the titer, the isotype profile and the switch of the anti-Ro/SSA antibodies in a cohort of patients affected by UCTD. Methods. One hundred selected patients with anti-Ro/SSA antibodies detected by counterimmunoelectrophoresis (CIE), and affected by UCTD with a mean follow-up of 7.6 years (SD 4.8 yrs.), were studied. The titer of IgA, IgG and IgM anti-Ro/SSA antibodies was determined in two different sera, obtained at the time of diagnosis and at the last visit, by ELISA with Ro/SSA recombinant proteins as substrate. Results. Thirty-five patients evolved from UCTD to a different connective tissue disease, while 65 showed a stable disease. Anti-Ro/SSA antibodies were detected in 91% and 97% of the patients, at baseline and during follow-up, respectively. IgG dominates the anti-Ro response. The titer of IgA, IgM and IgG anti-Ro/SSA did not differ significantly between the two groups of patients with UCTD. An increasing trend of IgG and IgA anti-Ro/SSA titer could be detected in patients evolving in primary Sjögren's Syndrome (pSS), but only the increase of IgG anti-Ro/SSA was significant (p = 0.0235). Conclusion. IgG dominates the anti-Ro/SSA response in patients with UCTD. No substantial change of the antibody isotype against Ro/SSA peptides could be observed during follow-up. The titer of IgG anti-Ro/ SSA significantly raised in the group of patients evolving in pSS.
| Original language | English |
|---|---|
| Pages (from-to) | 117-120 |
| Number of pages | 4 |
| Journal | Clinical and Experimental Rheumatology |
| Volume | 26 |
| Issue number | 1 |
| Publication status | Published - Jan 2008 |
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Keywords
- Anti-Ro/SSA antibodies
- Antibody titer
- Isotype switching
- Sjögren's syndrome
- Systemic lupus erythematosus
- Undifferentiated connective tissue disease
ASJC Scopus subject areas
- Rheumatology
- Immunology
Cite this
Isotype switching and titer variation of anti-Ro/SSA antibodies over time in 100 patients with undifferentiated connective tissue disease (UCTD). / Ceribelli, Angela; Cavazzana, Ilaria; Franceschini, Franco; Quinzanini, Marzia; Rizzini, Fabio Lodi; Cattaneo, Roberto.
In: Clinical and Experimental Rheumatology, Vol. 26, No. 1, 01.2008, p. 117-120.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Isotype switching and titer variation of anti-Ro/SSA antibodies over time in 100 patients with undifferentiated connective tissue disease (UCTD)
AU - Ceribelli, Angela
AU - Cavazzana, Ilaria
AU - Franceschini, Franco
AU - Quinzanini, Marzia
AU - Rizzini, Fabio Lodi
AU - Cattaneo, Roberto
PY - 2008/1
Y1 - 2008/1
N2 - Objective. To correlate the clinical course of the disease with the titer, the isotype profile and the switch of the anti-Ro/SSA antibodies in a cohort of patients affected by UCTD. Methods. One hundred selected patients with anti-Ro/SSA antibodies detected by counterimmunoelectrophoresis (CIE), and affected by UCTD with a mean follow-up of 7.6 years (SD 4.8 yrs.), were studied. The titer of IgA, IgG and IgM anti-Ro/SSA antibodies was determined in two different sera, obtained at the time of diagnosis and at the last visit, by ELISA with Ro/SSA recombinant proteins as substrate. Results. Thirty-five patients evolved from UCTD to a different connective tissue disease, while 65 showed a stable disease. Anti-Ro/SSA antibodies were detected in 91% and 97% of the patients, at baseline and during follow-up, respectively. IgG dominates the anti-Ro response. The titer of IgA, IgM and IgG anti-Ro/SSA did not differ significantly between the two groups of patients with UCTD. An increasing trend of IgG and IgA anti-Ro/SSA titer could be detected in patients evolving in primary Sjögren's Syndrome (pSS), but only the increase of IgG anti-Ro/SSA was significant (p = 0.0235). Conclusion. IgG dominates the anti-Ro/SSA response in patients with UCTD. No substantial change of the antibody isotype against Ro/SSA peptides could be observed during follow-up. The titer of IgG anti-Ro/ SSA significantly raised in the group of patients evolving in pSS.
AB - Objective. To correlate the clinical course of the disease with the titer, the isotype profile and the switch of the anti-Ro/SSA antibodies in a cohort of patients affected by UCTD. Methods. One hundred selected patients with anti-Ro/SSA antibodies detected by counterimmunoelectrophoresis (CIE), and affected by UCTD with a mean follow-up of 7.6 years (SD 4.8 yrs.), were studied. The titer of IgA, IgG and IgM anti-Ro/SSA antibodies was determined in two different sera, obtained at the time of diagnosis and at the last visit, by ELISA with Ro/SSA recombinant proteins as substrate. Results. Thirty-five patients evolved from UCTD to a different connective tissue disease, while 65 showed a stable disease. Anti-Ro/SSA antibodies were detected in 91% and 97% of the patients, at baseline and during follow-up, respectively. IgG dominates the anti-Ro response. The titer of IgA, IgM and IgG anti-Ro/SSA did not differ significantly between the two groups of patients with UCTD. An increasing trend of IgG and IgA anti-Ro/SSA titer could be detected in patients evolving in primary Sjögren's Syndrome (pSS), but only the increase of IgG anti-Ro/SSA was significant (p = 0.0235). Conclusion. IgG dominates the anti-Ro/SSA response in patients with UCTD. No substantial change of the antibody isotype against Ro/SSA peptides could be observed during follow-up. The titer of IgG anti-Ro/ SSA significantly raised in the group of patients evolving in pSS.
KW - Anti-Ro/SSA antibodies
KW - Antibody titer
KW - Isotype switching
KW - Sjögren's syndrome
KW - Systemic lupus erythematosus
KW - Undifferentiated connective tissue disease
UR - http://www.scopus.com/inward/record.url?scp=40749105733&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=40749105733&partnerID=8YFLogxK
M3 - Article
C2 - 18328157
AN - SCOPUS:40749105733
VL - 26
SP - 117
EP - 120
JO - Clinical and Experimental Rheumatology
JF - Clinical and Experimental Rheumatology
SN - 0392-856X
IS - 1
ER -