Italian Air Force acrobatic pilots are protected against flight-induced oxidative stress

Giada Dogliotti, Elena Dozio, Marco Agrifoglio, Elena Costa, Guido Broich, Alexis E. Malavazos, Fabrizio Palumbo, Massimiliano M. Corsi

Research output: Contribution to journalArticlepeer-review


Background/Aim: The purpose of this study was to assess the oxidative stress of aircraft pilots by evaluating different markers of oxidative stress and any imbalance between free radicals and antioxidants in plasma. Patients and Methods: A group of 13 supersonic aircraft pilots, following regular exercise and personalized diet, were compared with a group of 40 healthy controls. Oxidative stress indicators, such as reactive oxidative metabolites, carbonyl proteins, 8-hydroxy-2-deoxyguanosine and total antioxidant status, were evaluated after three months of intense flight. Results: Reactive oxygen metabolites, carbonyl protein and 8-hydroxy-2-deoxyguanosine plasma levels did not differ in supersonic aircraft pilots and healthy controls. The two groups also had similar total antioxidant status levels. Conclusion: We suggest that supersonic aircraft pilots working at high altitude, even if exposed to physiological stresses, can, with proper diet, regular exercise and periodical medical examinations, maintain a healthy balance between oxidant and antioxidant status.

Original languageEnglish
Pages (from-to)1013-1018
Number of pages6
JournalIn Vivo
Issue number6
Publication statusPublished - Nov 2011


  • 8-hydroxy-2-deoxyguanosine
  • Carbonyl proteins
  • Oxidative stress
  • Reactive oxygen metabolites

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology


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