Italian expert-based recommendations on the use of photo(chemo)therapy in the management of mycosis fungoides: Results of an e-Delphi consensus

Vieri Grandi, Antonello Baldo, Emilio Berti, Pietro Quaglino, Serena Rupoli, Mauro Alaibac, Silvia Alberti-Violetti, Paolo Amerio, Valeria Brazzelli, Pier Luigi Bruni, Piergiacomo Calzavara-Pinton, Aurora Parodi, Emanuele Cozzani, Martina Burlando, Maria Concetta Fargnoli, Daniele Gambini, Paolo Iacovelli, Alessia Pacifico, Caterina Longo, Giuseppe MonfrecolaAlberico Motolese, Giorgio Mozzicafreddo, Carlo Cota, Paolo Pigatto, Alessandro Pileri, Paola Savoia, Marco Simonacci, Marina Venturini, Annamaria Offidani, Elisa Molinelli, Michele Pellegrino, Emanuele Trovato, Roberta Piccinno, Karl Lawrence, Nicola Pimpinelli

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract Background Phototherapy is a mainstay for the treatment of MF. However, there is scarce evidence for its use, mostly due to the lack of a unified schedule. Aims The primary aim of this study was to establish the first structured, expert-based consensus regarding the indications and technical schedules of NB-UVB and PUVA for MF. The secondary aim was to determine the consensus level for each specific item. Materials & Methods E-delphi study. Item-specific expert consensus was defined as the number of ?Totally Agree? results to ≥80% of the panelists. Cronbach alpha index ≥0.7 was used as a measure of homogeneity in the responses among questions related to the same topic. Results Overall, there was a high homogeneity among responders (0.78). On specific topics, the highest grade was observed for technical items (0.8) followed by indications for early (0.73) and advanced stages (0.7). Conclusions Items related to the most canonical indications of phototherapy and to treatment schedules showed the highest agreements rates. There is consensus about the use of standardized treatment schedules for the induction and consolidation phases for NB-UVB and PUVA in MF.
Original languageEnglish
JournalPhoto-dermatology
Volumen/a
Issue numbern/a
DOIs
Publication statusPublished - 2021

Keywords

  • delphi study
  • evidence-based medicine
  • guideline
  • mycosis fungoides
  • phototherapy

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