Abstract
We performed an external and multicentric validation of the nomogram and prognostic index (PI) proposed by the MD Anderson Cancer Center to prognostically stratify chronic lymphocytic leukaemia (CLL) patients in 1502 CLL cases. All six parameters involved in the nomogram and PI (age, sex, absolute lymphocyte count, number of lymph node groups, Rai stage and β2-microglobulin) were independently associated with survival. The nomogram was accurate in predicting survival (c-index = 0·82). According to the PI, 38·7% of patients were at low-risk, 58·3% at intermediate-risk and 3% at high-risk. The estimated median survival times were: not reached for low-risk, 13·4 years for intermediate-risk and 3·4 years for high-risk. The estimated median and 5-year survival by PI were similar to those originally reported. The PI remained a predictor of survival when analysis was limited to 847 Rai stage 0 (P
Original language | English |
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Pages (from-to) | 224-232 |
Number of pages | 9 |
Journal | British Journal of Haematology |
Volume | 167 |
Issue number | 2 |
DOIs | |
Publication status | Published - Oct 1 2014 |
Keywords
- Chronic lymphocytic leukaemia
- Nomogram
- Prognosis
- Prognostic index
ASJC Scopus subject areas
- Hematology
- Medicine(all)