Italian external and multicentric validation of the MD Anderson Cancer Center nomogram and prognostic index for chronic lymphocytic leukaemia patients: Analysis of 1502 cases

Massimo Gentile, Francesca R. Mauro, Davide Rossi, Iolanda Vincelli, Giovanni Tripepi, Anna G. Recchia, Laura De Stefano, Melissa Campanelli, Diana Giannarelli, Sabrina Bossio, Lucio Morabito, Ernesto Vigna, Gianluca Gaidano, Robin Foà, Fortunato Morabito

Research output: Contribution to journalArticle

Abstract

We performed an external and multicentric validation of the nomogram and prognostic index (PI) proposed by the MD Anderson Cancer Center to prognostically stratify chronic lymphocytic leukaemia (CLL) patients in 1502 CLL cases. All six parameters involved in the nomogram and PI (age, sex, absolute lymphocyte count, number of lymph node groups, Rai stage and β2-microglobulin) were independently associated with survival. The nomogram was accurate in predicting survival (c-index = 0·82). According to the PI, 38·7% of patients were at low-risk, 58·3% at intermediate-risk and 3% at high-risk. The estimated median survival times were: not reached for low-risk, 13·4 years for intermediate-risk and 3·4 years for high-risk. The estimated median and 5-year survival by PI were similar to those originally reported. The PI remained a predictor of survival when analysis was limited to 847 Rai stage 0 (P 

Original languageEnglish
Pages (from-to)224-232
Number of pages9
JournalBritish Journal of Haematology
Volume167
Issue number2
DOIs
Publication statusPublished - Oct 1 2014

Keywords

  • Chronic lymphocytic leukaemia
  • Nomogram
  • Prognosis
  • Prognostic index

ASJC Scopus subject areas

  • Hematology
  • Medicine(all)

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    Gentile, M., Mauro, F. R., Rossi, D., Vincelli, I., Tripepi, G., Recchia, A. G., De Stefano, L., Campanelli, M., Giannarelli, D., Bossio, S., Morabito, L., Vigna, E., Gaidano, G., Foà, R., & Morabito, F. (2014). Italian external and multicentric validation of the MD Anderson Cancer Center nomogram and prognostic index for chronic lymphocytic leukaemia patients: Analysis of 1502 cases. British Journal of Haematology, 167(2), 224-232. https://doi.org/10.1111/bjh.13032