Italian guidelines for the diagnosis and treatment of patients with haemophilia and inhibitors

Alessandro Gringeri, P. M. Mannucci

Research output: Contribution to journalArticle

Abstract

The Italian Association of Haemophilia Centres reviewed and finally approved in November 2004 the new Italian Guidelines for the diagnosis and treatment of patients with clotting factor inhibitors. The recommendations have been based on the identification of levels of clinical evidence derived from the systematic review carried out in 2003 by the School of Health and Related Research, the University of Sheffield, UK, and further integrated by clinical studies published from 2003 to 2004. The Italian guidelines consist of six major domains concerning inhibitor definition, epidemiology, risk factors, diagnosis, inhibitor eradication, management of bleeding episodes, in patients with congenital and acquired coagulation disorders, with 121 statements, 59 synthesis and 54 recommendations. We report here recommendations and open issues concerning the diagnosis and monitoring of inhibitors, inhibitor eradication and the management of bleeding in patients with haemophilia A and B.

Original languageEnglish
Pages (from-to)611-619
Number of pages9
JournalHaemophilia
Volume11
Issue number6
DOIs
Publication statusPublished - Nov 2005

Keywords

  • Bleeding
  • Bypassing agents
  • Guidelines
  • Haemophilia
  • Immune tolerance induction
  • Inhibitors

ASJC Scopus subject areas

  • Hematology

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