Abstract
The Italian Association of Haemophilia Centres reviewed and finally approved in November 2004 the new Italian Guidelines for the diagnosis and treatment of patients with clotting factor inhibitors. The recommendations have been based on the identification of levels of clinical evidence derived from the systematic review carried out in 2003 by the School of Health and Related Research, the University of Sheffield, UK, and further integrated by clinical studies published from 2003 to 2004. The Italian guidelines consist of six major domains concerning inhibitor definition, epidemiology, risk factors, diagnosis, inhibitor eradication, management of bleeding episodes, in patients with congenital and acquired coagulation disorders, with 121 statements, 59 synthesis and 54 recommendations. We report here recommendations and open issues concerning the diagnosis and monitoring of inhibitors, inhibitor eradication and the management of bleeding in patients with haemophilia A and B.
| Original language | English |
|---|---|
| Pages (from-to) | 611-619 |
| Number of pages | 9 |
| Journal | Haemophilia |
| Volume | 11 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Nov 2005 |
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Keywords
- Bleeding
- Bypassing agents
- Guidelines
- Haemophilia
- Immune tolerance induction
- Inhibitors
ASJC Scopus subject areas
- Hematology
Cite this
Italian guidelines for the diagnosis and treatment of patients with haemophilia and inhibitors. / Gringeri, Alessandro; Mannucci, P. M.
In: Haemophilia, Vol. 11, No. 6, 11.2005, p. 611-619.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Italian guidelines for the diagnosis and treatment of patients with haemophilia and inhibitors
AU - Gringeri, Alessandro
AU - Mannucci, P. M.
PY - 2005/11
Y1 - 2005/11
N2 - The Italian Association of Haemophilia Centres reviewed and finally approved in November 2004 the new Italian Guidelines for the diagnosis and treatment of patients with clotting factor inhibitors. The recommendations have been based on the identification of levels of clinical evidence derived from the systematic review carried out in 2003 by the School of Health and Related Research, the University of Sheffield, UK, and further integrated by clinical studies published from 2003 to 2004. The Italian guidelines consist of six major domains concerning inhibitor definition, epidemiology, risk factors, diagnosis, inhibitor eradication, management of bleeding episodes, in patients with congenital and acquired coagulation disorders, with 121 statements, 59 synthesis and 54 recommendations. We report here recommendations and open issues concerning the diagnosis and monitoring of inhibitors, inhibitor eradication and the management of bleeding in patients with haemophilia A and B.
AB - The Italian Association of Haemophilia Centres reviewed and finally approved in November 2004 the new Italian Guidelines for the diagnosis and treatment of patients with clotting factor inhibitors. The recommendations have been based on the identification of levels of clinical evidence derived from the systematic review carried out in 2003 by the School of Health and Related Research, the University of Sheffield, UK, and further integrated by clinical studies published from 2003 to 2004. The Italian guidelines consist of six major domains concerning inhibitor definition, epidemiology, risk factors, diagnosis, inhibitor eradication, management of bleeding episodes, in patients with congenital and acquired coagulation disorders, with 121 statements, 59 synthesis and 54 recommendations. We report here recommendations and open issues concerning the diagnosis and monitoring of inhibitors, inhibitor eradication and the management of bleeding in patients with haemophilia A and B.
KW - Bleeding
KW - Bypassing agents
KW - Guidelines
KW - Haemophilia
KW - Immune tolerance induction
KW - Inhibitors
UR - http://www.scopus.com/inward/record.url?scp=27744516149&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27744516149&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2516.2005.01161.x
DO - 10.1111/j.1365-2516.2005.01161.x
M3 - Article
C2 - 16236111
AN - SCOPUS:27744516149
VL - 11
SP - 611
EP - 619
JO - Haemophilia
JF - Haemophilia
SN - 1351-8216
IS - 6
ER -