Italian Multicenter Study on Accuracy of 18F-FDG PET/CT in Assessing Bone Marrow Involvement in Pediatric Hodgkin Lymphoma

Angelina Cistaro, Laura Cassalia, Cinzia Ferrara, Natale Quartuccio, Laura Evangelista, Maurizio Bianchi, Franca Fagioli, Gianni Bisi, Sergio Baldari, Alessandro Zanella, Marta Pillon, Pietro Zucchetta, Marta Burei, Alessandra Sala, Luca Guerra, Priscilla Guglielmo, Roberta Burnelli, Stefano Panareo, Federica Scalorbi, Ilaria RambaldiArnoldo Piccardo, Alberto Garaventa, Demetrio Familiari, Maria Concetta Fornito, Egesta Lopci, Maurizio Mascarin, Corinna Altini, Cristina Ferrari, Teresa Perillo, Nicola Santoro, Eugenio Borsatti, Giuseppe Rubini

Research output: Contribution to journalArticle

Abstract

INTRODUCTION: The present study investigated the utility of fluorine-18 (18F) fluoro-2-deoxy-d-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in assessing bone marrow involvement (BMI) compared with bone marrow biopsy (BMB) in newly diagnosed pediatric Hodgkin lymphoma (HL).

PATIENTS AND METHODS: A total of 224 pediatric patients with HL underwent 18F-FDG PET/CT at staging. BMB or follow-up imaging was used as the standard of reference for the evaluation of BMI.

RESULTS: 18F-FDG PET/CT was negative for BMI in 193 cases. Of the 193 patients, the findings for 16 were originally reported as doubtful and later interpreted as negative for BMI, with negative findings on follow-up imaging and BMB. At BMB, 1 of the 16 patients (6.25%) had BMI. Of the 193 patients, 192 (99.48%) had negative BMB findings. Thus, the 18F-FDG PET/CT findings were truly negative for 192 patients and falsely negative for 1 patient for BMI.

CONCLUSION: 18F-FDG PET/CT showed high diagnostic performance in the evaluation of BMI in pediatric HL. Thus, BMB should be ideally reserved for patients presenting with doubtful 18F-FDG PET/CT findings for BMI.

Original languageEnglish
Pages (from-to)e267-e273
JournalClinical Lymphoma, Myeloma and Leukemia
Volume18
Issue number6
DOIs
Publication statusPublished - Jun 2018

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Hodgkin Disease
Multicenter Studies
Bone Marrow
Pediatrics
Glucose
Biopsy
Positron Emission Tomography Computed Tomography
Fluorine

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Italian Multicenter Study on Accuracy of 18F-FDG PET/CT in Assessing Bone Marrow Involvement in Pediatric Hodgkin Lymphoma. / Cistaro, Angelina; Cassalia, Laura; Ferrara, Cinzia; Quartuccio, Natale; Evangelista, Laura; Bianchi, Maurizio; Fagioli, Franca; Bisi, Gianni; Baldari, Sergio; Zanella, Alessandro; Pillon, Marta; Zucchetta, Pietro; Burei, Marta; Sala, Alessandra; Guerra, Luca; Guglielmo, Priscilla; Burnelli, Roberta; Panareo, Stefano; Scalorbi, Federica; Rambaldi, Ilaria; Piccardo, Arnoldo; Garaventa, Alberto; Familiari, Demetrio; Fornito, Maria Concetta; Lopci, Egesta; Mascarin, Maurizio; Altini, Corinna; Ferrari, Cristina; Perillo, Teresa; Santoro, Nicola; Borsatti, Eugenio; Rubini, Giuseppe.

In: Clinical Lymphoma, Myeloma and Leukemia, Vol. 18, No. 6, 06.2018, p. e267-e273.

Research output: Contribution to journalArticle

Cistaro, A, Cassalia, L, Ferrara, C, Quartuccio, N, Evangelista, L, Bianchi, M, Fagioli, F, Bisi, G, Baldari, S, Zanella, A, Pillon, M, Zucchetta, P, Burei, M, Sala, A, Guerra, L, Guglielmo, P, Burnelli, R, Panareo, S, Scalorbi, F, Rambaldi, I, Piccardo, A, Garaventa, A, Familiari, D, Fornito, MC, Lopci, E, Mascarin, M, Altini, C, Ferrari, C, Perillo, T, Santoro, N, Borsatti, E & Rubini, G 2018, 'Italian Multicenter Study on Accuracy of 18F-FDG PET/CT in Assessing Bone Marrow Involvement in Pediatric Hodgkin Lymphoma', Clinical Lymphoma, Myeloma and Leukemia, vol. 18, no. 6, pp. e267-e273. https://doi.org/10.1016/j.clml.2018.04.002
Cistaro, Angelina ; Cassalia, Laura ; Ferrara, Cinzia ; Quartuccio, Natale ; Evangelista, Laura ; Bianchi, Maurizio ; Fagioli, Franca ; Bisi, Gianni ; Baldari, Sergio ; Zanella, Alessandro ; Pillon, Marta ; Zucchetta, Pietro ; Burei, Marta ; Sala, Alessandra ; Guerra, Luca ; Guglielmo, Priscilla ; Burnelli, Roberta ; Panareo, Stefano ; Scalorbi, Federica ; Rambaldi, Ilaria ; Piccardo, Arnoldo ; Garaventa, Alberto ; Familiari, Demetrio ; Fornito, Maria Concetta ; Lopci, Egesta ; Mascarin, Maurizio ; Altini, Corinna ; Ferrari, Cristina ; Perillo, Teresa ; Santoro, Nicola ; Borsatti, Eugenio ; Rubini, Giuseppe. / Italian Multicenter Study on Accuracy of 18F-FDG PET/CT in Assessing Bone Marrow Involvement in Pediatric Hodgkin Lymphoma. In: Clinical Lymphoma, Myeloma and Leukemia. 2018 ; Vol. 18, No. 6. pp. e267-e273.
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title = "Italian Multicenter Study on Accuracy of 18F-FDG PET/CT in Assessing Bone Marrow Involvement in Pediatric Hodgkin Lymphoma",
abstract = "INTRODUCTION: The present study investigated the utility of fluorine-18 (18F) fluoro-2-deoxy-d-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in assessing bone marrow involvement (BMI) compared with bone marrow biopsy (BMB) in newly diagnosed pediatric Hodgkin lymphoma (HL).PATIENTS AND METHODS: A total of 224 pediatric patients with HL underwent 18F-FDG PET/CT at staging. BMB or follow-up imaging was used as the standard of reference for the evaluation of BMI.RESULTS: 18F-FDG PET/CT was negative for BMI in 193 cases. Of the 193 patients, the findings for 16 were originally reported as doubtful and later interpreted as negative for BMI, with negative findings on follow-up imaging and BMB. At BMB, 1 of the 16 patients (6.25{\%}) had BMI. Of the 193 patients, 192 (99.48{\%}) had negative BMB findings. Thus, the 18F-FDG PET/CT findings were truly negative for 192 patients and falsely negative for 1 patient for BMI.CONCLUSION: 18F-FDG PET/CT showed high diagnostic performance in the evaluation of BMI in pediatric HL. Thus, BMB should be ideally reserved for patients presenting with doubtful 18F-FDG PET/CT findings for BMI.",
author = "Angelina Cistaro and Laura Cassalia and Cinzia Ferrara and Natale Quartuccio and Laura Evangelista and Maurizio Bianchi and Franca Fagioli and Gianni Bisi and Sergio Baldari and Alessandro Zanella and Marta Pillon and Pietro Zucchetta and Marta Burei and Alessandra Sala and Luca Guerra and Priscilla Guglielmo and Roberta Burnelli and Stefano Panareo and Federica Scalorbi and Ilaria Rambaldi and Arnoldo Piccardo and Alberto Garaventa and Demetrio Familiari and Fornito, {Maria Concetta} and Egesta Lopci and Maurizio Mascarin and Corinna Altini and Cristina Ferrari and Teresa Perillo and Nicola Santoro and Eugenio Borsatti and Giuseppe Rubini",
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TY - JOUR

T1 - Italian Multicenter Study on Accuracy of 18F-FDG PET/CT in Assessing Bone Marrow Involvement in Pediatric Hodgkin Lymphoma

AU - Cistaro, Angelina

AU - Cassalia, Laura

AU - Ferrara, Cinzia

AU - Quartuccio, Natale

AU - Evangelista, Laura

AU - Bianchi, Maurizio

AU - Fagioli, Franca

AU - Bisi, Gianni

AU - Baldari, Sergio

AU - Zanella, Alessandro

AU - Pillon, Marta

AU - Zucchetta, Pietro

AU - Burei, Marta

AU - Sala, Alessandra

AU - Guerra, Luca

AU - Guglielmo, Priscilla

AU - Burnelli, Roberta

AU - Panareo, Stefano

AU - Scalorbi, Federica

AU - Rambaldi, Ilaria

AU - Piccardo, Arnoldo

AU - Garaventa, Alberto

AU - Familiari, Demetrio

AU - Fornito, Maria Concetta

AU - Lopci, Egesta

AU - Mascarin, Maurizio

AU - Altini, Corinna

AU - Ferrari, Cristina

AU - Perillo, Teresa

AU - Santoro, Nicola

AU - Borsatti, Eugenio

AU - Rubini, Giuseppe

N1 - Copyright © 2018 Elsevier Inc. All rights reserved.

PY - 2018/6

Y1 - 2018/6

N2 - INTRODUCTION: The present study investigated the utility of fluorine-18 (18F) fluoro-2-deoxy-d-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in assessing bone marrow involvement (BMI) compared with bone marrow biopsy (BMB) in newly diagnosed pediatric Hodgkin lymphoma (HL).PATIENTS AND METHODS: A total of 224 pediatric patients with HL underwent 18F-FDG PET/CT at staging. BMB or follow-up imaging was used as the standard of reference for the evaluation of BMI.RESULTS: 18F-FDG PET/CT was negative for BMI in 193 cases. Of the 193 patients, the findings for 16 were originally reported as doubtful and later interpreted as negative for BMI, with negative findings on follow-up imaging and BMB. At BMB, 1 of the 16 patients (6.25%) had BMI. Of the 193 patients, 192 (99.48%) had negative BMB findings. Thus, the 18F-FDG PET/CT findings were truly negative for 192 patients and falsely negative for 1 patient for BMI.CONCLUSION: 18F-FDG PET/CT showed high diagnostic performance in the evaluation of BMI in pediatric HL. Thus, BMB should be ideally reserved for patients presenting with doubtful 18F-FDG PET/CT findings for BMI.

AB - INTRODUCTION: The present study investigated the utility of fluorine-18 (18F) fluoro-2-deoxy-d-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in assessing bone marrow involvement (BMI) compared with bone marrow biopsy (BMB) in newly diagnosed pediatric Hodgkin lymphoma (HL).PATIENTS AND METHODS: A total of 224 pediatric patients with HL underwent 18F-FDG PET/CT at staging. BMB or follow-up imaging was used as the standard of reference for the evaluation of BMI.RESULTS: 18F-FDG PET/CT was negative for BMI in 193 cases. Of the 193 patients, the findings for 16 were originally reported as doubtful and later interpreted as negative for BMI, with negative findings on follow-up imaging and BMB. At BMB, 1 of the 16 patients (6.25%) had BMI. Of the 193 patients, 192 (99.48%) had negative BMB findings. Thus, the 18F-FDG PET/CT findings were truly negative for 192 patients and falsely negative for 1 patient for BMI.CONCLUSION: 18F-FDG PET/CT showed high diagnostic performance in the evaluation of BMI in pediatric HL. Thus, BMB should be ideally reserved for patients presenting with doubtful 18F-FDG PET/CT findings for BMI.

U2 - 10.1016/j.clml.2018.04.002

DO - 10.1016/j.clml.2018.04.002

M3 - Article

C2 - 29739722

VL - 18

SP - e267-e273

JO - Clinical Lymphoma, Myeloma and Leukemia

JF - Clinical Lymphoma, Myeloma and Leukemia

SN - 2152-2669

IS - 6

ER -