RISULTATI PRELIMINARI DELLO STUDIO MULTICENTRICO ITALIANO SULLA LAMOTRIGINA NELLE EPILESSIE RESISTENTI

Translated title of the contribution: Italian multicenter study on Lamotrigine in treatment resistant epilepsy: Preliminary results

A. Baruzzi, R. Di Virgilio, P. Zolo, S. Severi, L. M. Specchio, D. Nozzolillo, C. A. Defanti, E. Boati, C. A. Tassinari, R. Michelucci, L. Antonini, A. M. Perotti, G. Tabiadon, P. Biamino, S. Congia, U. Aguglia, F. Morelli, A. Falsaperla, A. Pavone

Research output: Contribution to journalArticle

Abstract

This is an open multicenter trial. 152 out of 235 enrolled patients have already entered the database. Lamotrigine (LTG) was added on to an existing antiepileptic drug. 13 patients did not complete the 12 week treatment period because of poor compliance, protocol deviations, intercurrent illness or adverse reactions (2 skin rashes, 1 headache, 1 nausea and vomiting). One patient was excluded from the analysis on seizure frequency because of uncertain results. 71 patients (51,4%) out of 138 who completed the study experienced at least 50% reduction in total seizure frequency. LTG showed favorable effects on other subjective measurements (mood) and was well tolerated.

Original languageItalian
Pages (from-to)165-169
Number of pages5
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number86-87
Publication statusPublished - 1994

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ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Baruzzi, A., Di Virgilio, R., Zolo, P., Severi, S., Specchio, L. M., Nozzolillo, D., Defanti, C. A., Boati, E., Tassinari, C. A., Michelucci, R., Antonini, L., Perotti, A. M., Tabiadon, G., Biamino, P., Congia, S., Aguglia, U., Morelli, F., Falsaperla, A., & Pavone, A. (1994). RISULTATI PRELIMINARI DELLO STUDIO MULTICENTRICO ITALIANO SULLA LAMOTRIGINA NELLE EPILESSIE RESISTENTI. Bollettino - Lega Italiana contro l'Epilessia, (86-87), 165-169.