Italian Multiple Sclerosis Database Network

M. Trojano, D. Paolicelli, V. Lepore, A. Fuiani, E. Di Monte, F. Pellegrini, P. Russo, P. Livrea, G. Comi

Research output: Contribution to journalArticlepeer-review


The Multiple Sclerosis Database Network (MSDN) is the first Italian multiple sclerosis (MS) registry. The preliminary results on the MSDN cohort demonstrated that the risk of disability progression, in a sample of 2090 MS patients, was reduced by about four- to five-fold in patients exposed to IFNβ for more than 4 years compared with patients exposed for up to 2 years. More recent results showed, in a subset of 1170 relapsing-remitting MS patients, of whom 918 were treated with IFNβ and 252 were untreated, that IFNβ-treated patients had a differential reduction in EDSS score change of -0.055 for each year of follow-up in comparison with the untreated group. These results provide significant information on the effectiveness of IFNβ treatment on long-term disability progression in MS.

Original languageEnglish
JournalNeurological Sciences
Issue numberSUPPL. 5
Publication statusPublished - Sep 2006


  • Databases
  • Databasing
  • MSDN
  • Multiple sclerosis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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