TY - JOUR
T1 - Italian pool of asbestos workers cohorts: asbestos related mortality by industrial sector and cumulative exposure
AU - Working Group Studio Multicentrico Italiano di Coorti di lavoratori dell’Amianto (SMICA)
AU - Magnani, Corrado
AU - Silvestri, Stefano
AU - Angelini, Alessia
AU - Ranucci, Alessandra
AU - Azzolina, Danila
AU - Cena, Tiziana
AU - Chellini, Elisabetta
AU - Merler, Enzo
AU - Pavone, Venere
AU - Miligi, Lucia
AU - Gorini, Giuseppe
AU - Bressan, Vittoria
AU - Girardi, Paolo
AU - Bauleo, Lisa
AU - Romeo, Elisa
AU - Luberto, Ferdinando
AU - Sala, Orietta
AU - Scarnato, Corrado
AU - Menegozzo, Simona
AU - Oddone, Enrico
AU - Tunesi, Sara
AU - Perticaroli, Patrizia
AU - Pettinari, Aldo
AU - Cuccaro, Francesco
AU - Mattioli, Stefano
AU - Baldassarre, Antonio
AU - Barone-Adesi, Francesco
AU - Musti, Marina
AU - Mirabelli, Dario
AU - Pirastu, Roberta
AU - Marinaccio, Alessandro
AU - Massari, Stefania
AU - Ferrante, Daniela
PY - 2020/9/23
Y1 - 2020/9/23
N2 - OBJECTIVE: Italy has been a large user of asbestos and asbestos containing materials until the 1992 ban. We present a pooled cohort study on long-term mortality in exposed workers.METHODS: Pool of 43 Italian asbestos cohorts (asbestos cement, rolling stock, shipbuilding, glasswork, harbors, insulation and other industries). SMRs were computed by industrial sector for the 1970-2010 period, for the major causes, using reference rates by age, sex, region and calendar period.RESULTS: The study included 51 801 subjects (5741 women): 55.9% alive, 42.6% died (cause known for 95%) and 1.5% lost to follow-up. Asbestos exposure was estimated at the plant and period levels. Asbestos related mortality was significantly increased. All industrial sectors showed increased mortality from pleural malignancies, and most also from peritoneal and lung cancer and asbestosis, with exposure related trend. Increased mortality was also observed for ovarian cancer and for bladder cancer.DISCUSSION: The study confirmed the increased risk for cancer of the lung, ovary, pleura and peritoneum but not of the larynx and the digestive tract. A large increase in mortality from asbestosis was observed.
AB - OBJECTIVE: Italy has been a large user of asbestos and asbestos containing materials until the 1992 ban. We present a pooled cohort study on long-term mortality in exposed workers.METHODS: Pool of 43 Italian asbestos cohorts (asbestos cement, rolling stock, shipbuilding, glasswork, harbors, insulation and other industries). SMRs were computed by industrial sector for the 1970-2010 period, for the major causes, using reference rates by age, sex, region and calendar period.RESULTS: The study included 51 801 subjects (5741 women): 55.9% alive, 42.6% died (cause known for 95%) and 1.5% lost to follow-up. Asbestos exposure was estimated at the plant and period levels. Asbestos related mortality was significantly increased. All industrial sectors showed increased mortality from pleural malignancies, and most also from peritoneal and lung cancer and asbestosis, with exposure related trend. Increased mortality was also observed for ovarian cancer and for bladder cancer.DISCUSSION: The study confirmed the increased risk for cancer of the lung, ovary, pleura and peritoneum but not of the larynx and the digestive tract. A large increase in mortality from asbestosis was observed.
U2 - 10.4415/ANN_20_03_07
DO - 10.4415/ANN_20_03_07
M3 - Article
C2 - 32959795
VL - 56
SP - 292
EP - 302
JO - Annali dell'Istituto Superiore di Sanita
JF - Annali dell'Istituto Superiore di Sanita
SN - 0021-2571
IS - 3
ER -