Italian real life experience with brentuximab vedotin: results of a large observational study on 234 relapsed/refractory Hodgkin's lymphoma

Cinzia Pellegrini, Alessandro Broccoli, Alessandro Pulsoni, Luigi Rigacci, Caterina Patti, Guido Gini, Donato Mannina, Monica Tani, Chiara Rusconi, Alessandra Romano, Anna Vanazzi, Barbara Botto, Armando Santoro, Stefan Hoaus, Gian Matteo Rigolin, Pellegrino Musto, Patrizio Mazza, Stefano Molica, Paolo Corradini, Angelo FamaFrancesco Gaudio, Michele Merli, Fioravante Ronconi, Giuseppe Gritti, Daniele Vallisa, Patrizia Tosi, Anna Marina Liberati, Antonello Pinto, Vincenzo Pavone, Filippo Gherlinzoni, Maria Paola Bianchi, Stefano Volpetti, Livio Trentin, Maria Cecilia Goldaniga, Maurizio Bonfichi, Amalia De Renzo, Corrado Schiavotto, Michele Spina, Angelo Michele Carella, Vittorio Stefoni, Lisa Argnani, Pier Luigi Zinzani

Research output: Contribution to journalArticle

Abstract

A large Italian multicenter observational retrospective study was conducted on the use of brentuximab vedotin (BV) for patients with relapsed Hodgkin's lymphoma (HL) to check if clinical trial results are confirmed even in a real life context. 234 CD30+ HL patients were enrolled. Best response was observed after a median of 4 cycles in 140 patients (59.8%): 74 (31.6%) patients obtained a complete response (CR) and 66 (28.2%) achieved a partial response (PR); overall response rate at the end of the treatment was 48.3% (62 CR and 51 PR). The best response rate was higher in the elderly subset: 14 (50%) CR and 5 (17.8%) PR. Disease free survival was 26.3% at 3 years and progression free survival 31.9% at 4.5 years. Duration of response did not differ for who achieved at least PR and then either did or did not undergo consolidative transplant. Overall, the treatment was well tolerated and no death has been linked to BV-induced toxicity. Our report confirms activity in elderly patients, duration of response unrelated to the consolidation with transplant procedure, the relevance of the CR status at first restaging, and the role of BV as a bridge to transplant for chemorefractory patients.

Original languageEnglish
Pages (from-to)91703-91710
Number of pages8
JournalOncotarget
Volume8
Issue number53
DOIs
Publication statusPublished - Oct 31 2017

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Life Change Events
Hodgkin Disease
Observational Studies
Transplants
Disease-Free Survival
cAC10-vcMMAE
Retrospective Studies
Clinical Trials
Therapeutics

Keywords

  • Journal Article

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Pellegrini, C., Broccoli, A., Pulsoni, A., Rigacci, L., Patti, C., Gini, G., ... Zinzani, P. L. (2017). Italian real life experience with brentuximab vedotin: results of a large observational study on 234 relapsed/refractory Hodgkin's lymphoma. Oncotarget, 8(53), 91703-91710. https://doi.org/10.18632/oncotarget.18114

Italian real life experience with brentuximab vedotin : results of a large observational study on 234 relapsed/refractory Hodgkin's lymphoma. / Pellegrini, Cinzia; Broccoli, Alessandro; Pulsoni, Alessandro; Rigacci, Luigi; Patti, Caterina; Gini, Guido; Mannina, Donato; Tani, Monica; Rusconi, Chiara; Romano, Alessandra; Vanazzi, Anna; Botto, Barbara; Santoro, Armando; Hoaus, Stefan; Rigolin, Gian Matteo; Musto, Pellegrino; Mazza, Patrizio; Molica, Stefano; Corradini, Paolo; Fama, Angelo; Gaudio, Francesco; Merli, Michele; Ronconi, Fioravante; Gritti, Giuseppe; Vallisa, Daniele; Tosi, Patrizia; Liberati, Anna Marina; Pinto, Antonello; Pavone, Vincenzo; Gherlinzoni, Filippo; Bianchi, Maria Paola; Volpetti, Stefano; Trentin, Livio; Goldaniga, Maria Cecilia; Bonfichi, Maurizio; De Renzo, Amalia; Schiavotto, Corrado; Spina, Michele; Carella, Angelo Michele; Stefoni, Vittorio; Argnani, Lisa; Zinzani, Pier Luigi.

In: Oncotarget, Vol. 8, No. 53, 31.10.2017, p. 91703-91710.

Research output: Contribution to journalArticle

Pellegrini, C, Broccoli, A, Pulsoni, A, Rigacci, L, Patti, C, Gini, G, Mannina, D, Tani, M, Rusconi, C, Romano, A, Vanazzi, A, Botto, B, Santoro, A, Hoaus, S, Rigolin, GM, Musto, P, Mazza, P, Molica, S, Corradini, P, Fama, A, Gaudio, F, Merli, M, Ronconi, F, Gritti, G, Vallisa, D, Tosi, P, Liberati, AM, Pinto, A, Pavone, V, Gherlinzoni, F, Bianchi, MP, Volpetti, S, Trentin, L, Goldaniga, MC, Bonfichi, M, De Renzo, A, Schiavotto, C, Spina, M, Carella, AM, Stefoni, V, Argnani, L & Zinzani, PL 2017, 'Italian real life experience with brentuximab vedotin: results of a large observational study on 234 relapsed/refractory Hodgkin's lymphoma', Oncotarget, vol. 8, no. 53, pp. 91703-91710. https://doi.org/10.18632/oncotarget.18114
Pellegrini, Cinzia ; Broccoli, Alessandro ; Pulsoni, Alessandro ; Rigacci, Luigi ; Patti, Caterina ; Gini, Guido ; Mannina, Donato ; Tani, Monica ; Rusconi, Chiara ; Romano, Alessandra ; Vanazzi, Anna ; Botto, Barbara ; Santoro, Armando ; Hoaus, Stefan ; Rigolin, Gian Matteo ; Musto, Pellegrino ; Mazza, Patrizio ; Molica, Stefano ; Corradini, Paolo ; Fama, Angelo ; Gaudio, Francesco ; Merli, Michele ; Ronconi, Fioravante ; Gritti, Giuseppe ; Vallisa, Daniele ; Tosi, Patrizia ; Liberati, Anna Marina ; Pinto, Antonello ; Pavone, Vincenzo ; Gherlinzoni, Filippo ; Bianchi, Maria Paola ; Volpetti, Stefano ; Trentin, Livio ; Goldaniga, Maria Cecilia ; Bonfichi, Maurizio ; De Renzo, Amalia ; Schiavotto, Corrado ; Spina, Michele ; Carella, Angelo Michele ; Stefoni, Vittorio ; Argnani, Lisa ; Zinzani, Pier Luigi. / Italian real life experience with brentuximab vedotin : results of a large observational study on 234 relapsed/refractory Hodgkin's lymphoma. In: Oncotarget. 2017 ; Vol. 8, No. 53. pp. 91703-91710.
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abstract = "A large Italian multicenter observational retrospective study was conducted on the use of brentuximab vedotin (BV) for patients with relapsed Hodgkin's lymphoma (HL) to check if clinical trial results are confirmed even in a real life context. 234 CD30+ HL patients were enrolled. Best response was observed after a median of 4 cycles in 140 patients (59.8{\%}): 74 (31.6{\%}) patients obtained a complete response (CR) and 66 (28.2{\%}) achieved a partial response (PR); overall response rate at the end of the treatment was 48.3{\%} (62 CR and 51 PR). The best response rate was higher in the elderly subset: 14 (50{\%}) CR and 5 (17.8{\%}) PR. Disease free survival was 26.3{\%} at 3 years and progression free survival 31.9{\%} at 4.5 years. Duration of response did not differ for who achieved at least PR and then either did or did not undergo consolidative transplant. Overall, the treatment was well tolerated and no death has been linked to BV-induced toxicity. Our report confirms activity in elderly patients, duration of response unrelated to the consolidation with transplant procedure, the relevance of the CR status at first restaging, and the role of BV as a bridge to transplant for chemorefractory patients.",
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AU - Pellegrini, Cinzia

AU - Broccoli, Alessandro

AU - Pulsoni, Alessandro

AU - Rigacci, Luigi

AU - Patti, Caterina

AU - Gini, Guido

AU - Mannina, Donato

AU - Tani, Monica

AU - Rusconi, Chiara

AU - Romano, Alessandra

AU - Vanazzi, Anna

AU - Botto, Barbara

AU - Santoro, Armando

AU - Hoaus, Stefan

AU - Rigolin, Gian Matteo

AU - Musto, Pellegrino

AU - Mazza, Patrizio

AU - Molica, Stefano

AU - Corradini, Paolo

AU - Fama, Angelo

AU - Gaudio, Francesco

AU - Merli, Michele

AU - Ronconi, Fioravante

AU - Gritti, Giuseppe

AU - Vallisa, Daniele

AU - Tosi, Patrizia

AU - Liberati, Anna Marina

AU - Pinto, Antonello

AU - Pavone, Vincenzo

AU - Gherlinzoni, Filippo

AU - Bianchi, Maria Paola

AU - Volpetti, Stefano

AU - Trentin, Livio

AU - Goldaniga, Maria Cecilia

AU - Bonfichi, Maurizio

AU - De Renzo, Amalia

AU - Schiavotto, Corrado

AU - Spina, Michele

AU - Carella, Angelo Michele

AU - Stefoni, Vittorio

AU - Argnani, Lisa

AU - Zinzani, Pier Luigi

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N2 - A large Italian multicenter observational retrospective study was conducted on the use of brentuximab vedotin (BV) for patients with relapsed Hodgkin's lymphoma (HL) to check if clinical trial results are confirmed even in a real life context. 234 CD30+ HL patients were enrolled. Best response was observed after a median of 4 cycles in 140 patients (59.8%): 74 (31.6%) patients obtained a complete response (CR) and 66 (28.2%) achieved a partial response (PR); overall response rate at the end of the treatment was 48.3% (62 CR and 51 PR). The best response rate was higher in the elderly subset: 14 (50%) CR and 5 (17.8%) PR. Disease free survival was 26.3% at 3 years and progression free survival 31.9% at 4.5 years. Duration of response did not differ for who achieved at least PR and then either did or did not undergo consolidative transplant. Overall, the treatment was well tolerated and no death has been linked to BV-induced toxicity. Our report confirms activity in elderly patients, duration of response unrelated to the consolidation with transplant procedure, the relevance of the CR status at first restaging, and the role of BV as a bridge to transplant for chemorefractory patients.

AB - A large Italian multicenter observational retrospective study was conducted on the use of brentuximab vedotin (BV) for patients with relapsed Hodgkin's lymphoma (HL) to check if clinical trial results are confirmed even in a real life context. 234 CD30+ HL patients were enrolled. Best response was observed after a median of 4 cycles in 140 patients (59.8%): 74 (31.6%) patients obtained a complete response (CR) and 66 (28.2%) achieved a partial response (PR); overall response rate at the end of the treatment was 48.3% (62 CR and 51 PR). The best response rate was higher in the elderly subset: 14 (50%) CR and 5 (17.8%) PR. Disease free survival was 26.3% at 3 years and progression free survival 31.9% at 4.5 years. Duration of response did not differ for who achieved at least PR and then either did or did not undergo consolidative transplant. Overall, the treatment was well tolerated and no death has been linked to BV-induced toxicity. Our report confirms activity in elderly patients, duration of response unrelated to the consolidation with transplant procedure, the relevance of the CR status at first restaging, and the role of BV as a bridge to transplant for chemorefractory patients.

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