Italian Society of Arterial Hypertension (SIIA) Position Paper on the Role of Renal Denervation in the Management of the Difficult-to-Treat Hypertensive Patient

Rosa Maria Bruno, Stefano Taddei, Claudio Borghi, Furio Colivicchi, Giovambattista Desideri, Guido Grassi, Alberto Mazza, Maria Lorenza Muiesan, Gianfranco Parati, Roberto Pontremoli, Bruno Trimarco, Massimo Volpe, Claudio Ferri

Research output: Contribution to journalReview article

Abstract

Renal denervation is a device-based procedure for hypertension for which safety and efficacy has been demonstrated. At present, its clinical use is still matter of debate, despite the most recent clinical trials have shown promising results with new-generation devices in various hypertensive populations. This position paper was deemed necessary by the Italian Society of Arterial Hypertension, in order to provide indications about the applications of renal denervation in the clinical setting. A state-of-the art review of the literature, focusing on safety and efficacy data, is provided. Furthermore, based on current evidence and expert consensus, clinical profiles of possible candidates for renal denervation are proposed. The selection process should take into account not only blood pressure values, global cardiovascular risk profile, but also drug adherence and tolerability and patient preferences. This position paper also defines minimum requirements for renal denervation selection centers and a flowchart for the difficult-to-treat hypertensive patient. Further studies are needed to support these preliminary indications, which are based on expert-consensus only.

Original languageEnglish
Pages (from-to)109-117
Number of pages9
JournalHigh Blood Pressure and Cardiovascular Prevention
Volume27
Issue number2
DOIs
Publication statusPublished - Apr 2020

Keywords

  • Ablation Techniques/adverse effects
  • Antihypertensive Agents/therapeutic use
  • Arterial Pressure/drug effects
  • Clinical Decision-Making
  • Decision Support Techniques
  • Drug Resistance
  • Humans
  • Hypertension/diagnosis
  • Kidney/blood supply
  • Medication Adherence
  • Patient Safety
  • Patient Selection
  • Renal Artery/innervation
  • Risk Factors
  • Sympathectomy/adverse effects
  • Treatment Outcome

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    Bruno, R. M., Taddei, S., Borghi, C., Colivicchi, F., Desideri, G., Grassi, G., Mazza, A., Muiesan, M. L., Parati, G., Pontremoli, R., Trimarco, B., Volpe, M., & Ferri, C. (2020). Italian Society of Arterial Hypertension (SIIA) Position Paper on the Role of Renal Denervation in the Management of the Difficult-to-Treat Hypertensive Patient. High Blood Pressure and Cardiovascular Prevention, 27(2), 109-117. https://doi.org/10.1007/s40292-020-00367-0