Italian Society of Hematology practice guidelines for the management of iron overload in thalassemia major and related disorders

Emanuele Angelucci, Giovanni Barosi, Clara Camaschella, Maria Domenica Cappellini, Mario Cazzola, Renzo Galanello, Monia Marchetti, Antonio Piga, Sante Tura

Research output: Contribution to journalArticlepeer-review

Abstract

New measures of iron accumulation in liver and heart (superconducting quantum inference device and magnetic resonance imaging), and oral iron chelators (deferiprone and deferasirox) are available for managing iron overload in thalassemia major. To assure appropriate use of these new health technologies, the Italian Society of Hematology appointed a panel of experts to produce clinical practiceguidelines for the management of iron overload in thalassemia major and related disorders. The analytical hierarchy process, a technique for multicriteria decision analysis, was applied to relevant key questions in order to identify the alternative strategies, generate explicit criteria for their evaluation, and check how well the alternatives fulfilled the criteria. The result of a comprehensive systematic review of articles released from 1990 to 2007 was used as a source of scientific evidence to compare the decisional options pairwise, and select the final recommendation. Every step in the model was developed from questionnaires and group discussion. The resulting recommendations advise about which examination to carry out in order to plan iron chelation therapy, when to start iron chelation, which iron chelator to choose in regularly transfused patients, how to monitor iron chelation therapy, and when and how to switch standard therapy.

Original languageEnglish
Pages (from-to)741-752
Number of pages12
JournalHaematologica
Volume93
Issue number5
DOIs
Publication statusPublished - May 2008

Keywords

  • Clinical practice guidelines
  • Deferasirox
  • Deferiprone
  • Deferoxamine
  • Sickle cell anemia
  • Systematic review
  • Thalassemia major

ASJC Scopus subject areas

  • Hematology

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