Italian validation of INQoL, a quality of life questionnaire for adults with muscle diseases

V. A. Sansone, M. Panzeri, M. Montanari, G. Apolone, S. Gandossini, M. R. Rose, L. Politano, C. Solimene, G. Siciliano, L. Volpi, C. Angelini, A. Palmieri, A. Toscano, O. Musumeci, T. Mongini, L. Vercelli, R. Massa, M. B. Panico, M. Grandi, G. Meola

Research output: Contribution to journalArticle


Background and purpose: A quality of life (QoL) questionnaire for neuromuscular diseases was recently constructed and validated in the United Kingdom in a sample of adult patients with a variety of muscle disorders. Preliminary results suggested it could be a more relevant and practical measure of QoL in muscle diseases than generic health measures of QoL. The purpose of our work was: (i) To validate INQoL in Italy on a larger sample of adult patients with muscle diseases (ii) to compare INQoL to SF-36. Methods: We have translated into Italian and applied language adaptations to the original UK INQoL version. We studied 1092 patients with different muscle disorders and performed (i) test-retest reliability (n = 80); (ii) psychometric (n = 345), known-group (n = 1092), external criterion (n = 70), and concurrent validity with SF-36 (n = 183). Results: We have translated and formally validated the Italian version of INQoL confirming and extending results obtained in the United Kingdom. In addition to good results in terms of reliability, known-group and criterion validity, a comparison with the SF-36 scales showed a stronger association between INQoL total index and SF-36 physical (r = -0.72) than mental (r = -0.38) summary health indexes. When considering comparable domains of INQoL and SF-36 with respect to an objective measure of muscle strength assessment (MMRC), regression analysis showed a stronger correlation using INQoL rather than SF-36 scores. Conclusions: INQoL is recommended to assess QoL in muscle diseases because of its ability to capture physical limitations that are specifically relevant to the muscle condition.

Original languageEnglish
Pages (from-to)1178-1187
Number of pages10
JournalEuropean Journal of Neurology
Issue number9
Publication statusPublished - Sep 2010


  • INQoL
  • muscle diseases
  • quality of life
  • SF-36

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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    Sansone, V. A., Panzeri, M., Montanari, M., Apolone, G., Gandossini, S., Rose, M. R., Politano, L., Solimene, C., Siciliano, G., Volpi, L., Angelini, C., Palmieri, A., Toscano, A., Musumeci, O., Mongini, T., Vercelli, L., Massa, R., Panico, M. B., Grandi, M., & Meola, G. (2010). Italian validation of INQoL, a quality of life questionnaire for adults with muscle diseases. European Journal of Neurology, 17(9), 1178-1187.