Itch: A HECT-type E3 ligase regulating immunity, skin and cancer

G. Melino, E. Gallagher, R. I. Aqeilan, R. Knight, A. Peschiaroli, M. Rossi, F. Scialpi, M. Malatesta, L. Zocchi, G. Browne, A. Ciechanover, F. Bernassola

Research output: Contribution to journalArticle

Abstract

The HECT-type E3 ubiquitin ligase (E3) Itch is absent in the non-agouti-lethal 18H or Itchy mice, which develop a severe immunological disease, including lung and stomach inflammation and hyperplasia of lymphoid and hematopoietic cells. The involvement of Itch in multiple signaling pathways and pathological conditions is presently an area of extensive scientific interest. This review aims to bring together a growing body of work exploring Itch-regulated biological processes, and to highlight recent discoveries on the regulatory mechanisms modulating its catalytic activity and substrate recognition capability. Our contribution is also an endeavor to correlate Itch substrate specificity with the pathological defects manifested by the mutant Itchy mice.

Original languageEnglish
Pages (from-to)1103-1112
Number of pages10
JournalCell Death and Differentiation
Volume15
Issue number7
DOIs
Publication statusPublished - Jul 2008

ASJC Scopus subject areas

  • Cell Biology

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    Melino, G., Gallagher, E., Aqeilan, R. I., Knight, R., Peschiaroli, A., Rossi, M., Scialpi, F., Malatesta, M., Zocchi, L., Browne, G., Ciechanover, A., & Bernassola, F. (2008). Itch: A HECT-type E3 ligase regulating immunity, skin and cancer. Cell Death and Differentiation, 15(7), 1103-1112. https://doi.org/10.1038/cdd.2008.60