Abstract
BACKGROUND: Our aim was to analyze the safety and efficacy of iterative cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (iCRS-HIPEC) in patients with peritoneal recurrence from different tumor types.
PATIENTS AND METHODS: Data on indications, intraoperative findings and postoperative outcome of all patients treated with iCRS-HIPEC at our Institution were reviewed.
RESULTS: Between 2010-2018, 10 iCRS-HIPEC procedures for peritoneal recurrence in eight patients were performed. The median peritoneal cancer index was 14.5 (range=2-33). Completeness of cytoreduction was CC0-1 in most cases (9/10). Three grade III-IV complications (two intestinal fistulas, one bleeding) were recorded and there was no operative mortality. After a median follow-up of 19.5 months, six patients experienced recurrence after a median of 12.5 months.
CONCLUSION: iCRS-HIPEC is a safe procedure in selected patients with recurrent peritoneal surface malignancies. Selection criteria still remain questionable and need to be further evaluated in large cooperative multi-institution studies.
| Original language | English |
|---|---|
| Pages (from-to) | 5521-5524 |
| Number of pages | 4 |
| Journal | Anticancer Research |
| Volume | 38 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 2018 |
Keywords
- Adult
- Aged
- Cytoreduction Surgical Procedures/adverse effects
- Female
- Humans
- Hyperthermia, Induced/adverse effects
- Italy
- Male
- Middle Aged
- Peritoneal Neoplasms/secondary
- Postoperative Complications/etiology
- Recurrence
- Retrospective Studies
- Risk Factors
- Time Factors
- Treatment Outcome
- Young Adult