Iterative EM reconstruction of cardiac small animal PET images using system point spread function modelling and MAP with anatomical priors

Antonello E. Spinelli, Giacomo Fiacchi, Daniela D'Ambrosio, Stefano Boschi, Roberto Franchi, Mario Marengo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The goal of this work was to improve the imagequality of small animal PET images by introducing in the reconstruction process the true system point spread function(PSF) and an anatomical image prior (MAP). The algorithm was tested on a mouse heart digital phantom (myocardium and ventricles) and on real acquired images of the Derenzo phantom and of a real mouse. For both the acquisitions two radiotracers were used, I8-FDG and 68Ga-chloride. A comparison between standard EM reconstruction and EM with PSF modelling and anatomical prior was performed. The system PSF was assumed to be a Gaussian function and its Full Width Half Maximum (FWHM) was modelled to be spatially variant in order to simulate the diITerent spatial resolution inside the scanner field of view. A visual comparison of the images reconstructed with the standard EM and with the proposed image reconstruction method showed that the reconstructed images look much sharper and are very close to the true ones when using EM with PSF modelling and natomical prior.

Original languageEnglish
Title of host publicationIEEE Nuclear Science Symposium Conference Record
Pages5147-5152
Number of pages6
DOIs
Publication statusPublished - 2008
Event2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008 - Dresden, Germany
Duration: Oct 19 2008Oct 25 2008

Other

Other2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008
CountryGermany
CityDresden
Period10/19/0810/25/08

Keywords

  • Point spread function, MAP, Anatomical Prior,Moby.

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

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