Iterative EM reconstruction of cardiac small animal PET images using system point spread function modelling and MAP with anatomical priors

A. E. Spinelli, G. Fiacchi, D. D'Ambrosio, P. Cilibrizzi, C. Lamberti, G. Baldazzi, S. Boschi, R. Franchi, M. Marengo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The goal of this work was to improve the image quality of small animal PET images by introducing in the reconstruction process the true system point spread function (PSF) and an anatomical image prior. Simulations were performed using a mouse heart phantom (myocardium and ventricles) and a comparison between standard EM reconstruction and EM with PSF modelling and anatomical prior was performed. The system PSF was assumed to be a Gaussian function and its Full Width Half Maximum (FWHM) was modelled to be spatially variant in order to simulate the different spatial resolution inside the scanner field of view. A visual comparison of the images reconstructed with the standard EM and with the proposed image reconstruction method showed that the reconstructed images look much sharper and are very close to the true ones when using EM with PSF modelling and anatomical prior.

Original languageEnglish
Title of host publicationComputers in Cardiology
Pages333-336
Number of pages4
Volume35
DOIs
Publication statusPublished - 2008
EventComputers in Cardiology 2008, CAR - Bologna, Italy
Duration: Sep 14 2008Sep 17 2008

Other

OtherComputers in Cardiology 2008, CAR
CountryItaly
CityBologna
Period9/14/089/17/08

ASJC Scopus subject areas

  • Computer Science Applications
  • Cardiology and Cardiovascular Medicine

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