It's HIP to be a hub

New trends for old-fashioned proteins

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Many endocytic proteins shuttle between the nucleus and the cytoplasm; however, their putative function in the nucleus is unclear. Now, new data demonstrate that huntingtin interacting protein 1 (HIP1), an endocytic protein, modulates the transcriptional activity of nuclear hormone receptors. In network theory, therefore, HIP1 can be regarded as a hub connecting heterogeneous functional "territories:" a possibility with important physiological and pathological implications.

Original languageEnglish
Pages (from-to)169-171
Number of pages3
JournalJournal of Cell Biology
Volume170
Issue number2
DOIs
Publication statusPublished - Jul 2005

Fingerprint

Cytoplasmic and Nuclear Receptors
Cytoplasm
Proteins
Huntingtin Protein

ASJC Scopus subject areas

  • Cell Biology

Cite this

It's HIP to be a hub : New trends for old-fashioned proteins. / Vecchi, Manuela; Di Fiore, Pier Paolo.

In: Journal of Cell Biology, Vol. 170, No. 2, 07.2005, p. 169-171.

Research output: Contribution to journalArticle

@article{ca81c59f8bb040cdbdfb09a33234d030,
title = "It's HIP to be a hub: New trends for old-fashioned proteins",
abstract = "Many endocytic proteins shuttle between the nucleus and the cytoplasm; however, their putative function in the nucleus is unclear. Now, new data demonstrate that huntingtin interacting protein 1 (HIP1), an endocytic protein, modulates the transcriptional activity of nuclear hormone receptors. In network theory, therefore, HIP1 can be regarded as a hub connecting heterogeneous functional {"}territories:{"} a possibility with important physiological and pathological implications.",
author = "Manuela Vecchi and {Di Fiore}, {Pier Paolo}",
year = "2005",
month = "7",
doi = "10.1083/jcb.200506039",
language = "English",
volume = "170",
pages = "169--171",
journal = "Journal of Cell Biology",
issn = "0021-9525",
publisher = "Rockefeller University Press",
number = "2",

}

TY - JOUR

T1 - It's HIP to be a hub

T2 - New trends for old-fashioned proteins

AU - Vecchi, Manuela

AU - Di Fiore, Pier Paolo

PY - 2005/7

Y1 - 2005/7

N2 - Many endocytic proteins shuttle between the nucleus and the cytoplasm; however, their putative function in the nucleus is unclear. Now, new data demonstrate that huntingtin interacting protein 1 (HIP1), an endocytic protein, modulates the transcriptional activity of nuclear hormone receptors. In network theory, therefore, HIP1 can be regarded as a hub connecting heterogeneous functional "territories:" a possibility with important physiological and pathological implications.

AB - Many endocytic proteins shuttle between the nucleus and the cytoplasm; however, their putative function in the nucleus is unclear. Now, new data demonstrate that huntingtin interacting protein 1 (HIP1), an endocytic protein, modulates the transcriptional activity of nuclear hormone receptors. In network theory, therefore, HIP1 can be regarded as a hub connecting heterogeneous functional "territories:" a possibility with important physiological and pathological implications.

UR - http://www.scopus.com/inward/record.url?scp=22944483490&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22944483490&partnerID=8YFLogxK

U2 - 10.1083/jcb.200506039

DO - 10.1083/jcb.200506039

M3 - Article

VL - 170

SP - 169

EP - 171

JO - Journal of Cell Biology

JF - Journal of Cell Biology

SN - 0021-9525

IS - 2

ER -