It's HIP to be a hub: New trends for old-fashioned proteins

Manuela Vecchi, Pier Paolo Di Fiore

Research output: Contribution to journalArticlepeer-review


Many endocytic proteins shuttle between the nucleus and the cytoplasm; however, their putative function in the nucleus is unclear. Now, new data demonstrate that huntingtin interacting protein 1 (HIP1), an endocytic protein, modulates the transcriptional activity of nuclear hormone receptors. In network theory, therefore, HIP1 can be regarded as a hub connecting heterogeneous functional "territories:" a possibility with important physiological and pathological implications.

Original languageEnglish
Pages (from-to)169-171
Number of pages3
JournalJournal of Cell Biology
Issue number2
Publication statusPublished - Jul 2005

ASJC Scopus subject areas

  • Cell Biology


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