IUI and uterine lavage of in vivo–produced blastocysts for PGT purposes: is it a technically and ethically reasonable perspective? Is it actually needed?

On behalf of the Italian Society of Embryology, Reproduction and Research (SIERR)

Research output: Contribution to journalArticlepeer-review

Abstract

A recent study by Munné et al. portrayed a protocol to retrieve in vivo produced blastocysts after IUI and uterine lavage for preimplantation genetic testing (PGT) purposes. The authors claimed this protocol might represent a reasonable future perspective for patients who do not want to undergo IVF, but still want to be informed about their embryos’ genetic/chromosomal defects. Although the intent of making PGT available also to patients who cannot or do not need to undergo IVF is respectable, the value of this study is undermined by severe technical and ethical issues. Munné and colleagues’ paper was discussed within the executive committee (i.e., president and vice-president of the society, director and vice-director of the scientific committee, secretariat, and counselors), the special interest group in reproductive genetics, the scientific committee, and the collegio dei probiviri of the Italian Society of Embryology, Reproduction and Research (SIERR). The points raised from this discussion are summarized in this opinion paper.

Original languageEnglish
Pages (from-to)1579-1582
Number of pages4
JournalJournal of Assisted Reproduction and Genetics
Volume37
Issue number7
DOIs
Publication statusPublished - Jul 1 2020

Keywords

  • Blastocyst
  • Ethics
  • PGT
  • Preimplantation development
  • Uterine lavage

ASJC Scopus subject areas

  • Reproductive Medicine
  • Genetics
  • Obstetrics and Gynaecology
  • Developmental Biology
  • Genetics(clinical)

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