IV‐S neuroblastoma: A cooperative study of 30 children

Antonia F. Mancini, Pasquale Rosito, Arnaldo Vitelli, Paolo Paolucci, Vico Vecchi, Guido Paolucci, Bruno de Bernardi, Giovanni Calculli, Modesto Carli, Manuel Castello, Antonietta Marchi, Fausta Massolo, Renato Mastrangelo, Guido Pastore, Clotilde Pianca, Giulio Andrea Zanazzo

Research output: Contribution to journalArticlepeer-review


The clinical features of 30 children with IVS neuroblastoma have been reviewed. They were treated at 11 Italian pediatric institutions in the period 1970‐1981. Patients with IV‐S neuroblastoma comprise 6.1% of all the neuroblastoma cases observed during that period. The age at diagnosis ranged from birth to 11 months (mean, 3 months). The distribution of “primary” lesions was of interest. The adrenal gland was affected most often (57% of patients), but tumors of the chest and neck were also encountered. No specific “primary” lesion was identified in ten children. The most frequent site of widespread disease was the liver (87%). Neither the size of the “primary” tumor, nor the number or size of subcutaneous nodules was of prognostic significance. Unfavorable features were age less than 2 months and clinical signs of pulmonary, renal, or hepatic embarrassment. These data confirm the need for prompt intervention in the infant who is suffering from compression of these vital structures by the enlarged liver. Radiation therapy is to be preferred for this purpose, because of the often severe toxicity that is associated with chemotherapy in infants. One, and possibly two babies in this series died of chemotherapy‐related complications.

Original languageEnglish
Pages (from-to)155-161
Number of pages7
JournalMedical and Pediatric Oncology
Issue number3
Publication statusPublished - 1984


  • hepatomegaly
  • metastatic neuroblastoma
  • regression of neuroblastoma
  • stage IV‐S neuroblastoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research


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