TY - JOUR
T1 - IV‐S neuroblastoma
T2 - A cooperative study of 30 children
AU - Mancini, Antonia F.
AU - Rosito, Pasquale
AU - Vitelli, Arnaldo
AU - Paolucci, Paolo
AU - Vecchi, Vico
AU - Paolucci, Guido
AU - de Bernardi, Bruno
AU - Calculli, Giovanni
AU - Carli, Modesto
AU - Castello, Manuel
AU - Marchi, Antonietta
AU - Massolo, Fausta
AU - Mastrangelo, Renato
AU - Pastore, Guido
AU - Pianca, Clotilde
AU - Zanazzo, Giulio Andrea
PY - 1984
Y1 - 1984
N2 - The clinical features of 30 children with IVS neuroblastoma have been reviewed. They were treated at 11 Italian pediatric institutions in the period 1970‐1981. Patients with IV‐S neuroblastoma comprise 6.1% of all the neuroblastoma cases observed during that period. The age at diagnosis ranged from birth to 11 months (mean, 3 months). The distribution of “primary” lesions was of interest. The adrenal gland was affected most often (57% of patients), but tumors of the chest and neck were also encountered. No specific “primary” lesion was identified in ten children. The most frequent site of widespread disease was the liver (87%). Neither the size of the “primary” tumor, nor the number or size of subcutaneous nodules was of prognostic significance. Unfavorable features were age less than 2 months and clinical signs of pulmonary, renal, or hepatic embarrassment. These data confirm the need for prompt intervention in the infant who is suffering from compression of these vital structures by the enlarged liver. Radiation therapy is to be preferred for this purpose, because of the often severe toxicity that is associated with chemotherapy in infants. One, and possibly two babies in this series died of chemotherapy‐related complications.
AB - The clinical features of 30 children with IVS neuroblastoma have been reviewed. They were treated at 11 Italian pediatric institutions in the period 1970‐1981. Patients with IV‐S neuroblastoma comprise 6.1% of all the neuroblastoma cases observed during that period. The age at diagnosis ranged from birth to 11 months (mean, 3 months). The distribution of “primary” lesions was of interest. The adrenal gland was affected most often (57% of patients), but tumors of the chest and neck were also encountered. No specific “primary” lesion was identified in ten children. The most frequent site of widespread disease was the liver (87%). Neither the size of the “primary” tumor, nor the number or size of subcutaneous nodules was of prognostic significance. Unfavorable features were age less than 2 months and clinical signs of pulmonary, renal, or hepatic embarrassment. These data confirm the need for prompt intervention in the infant who is suffering from compression of these vital structures by the enlarged liver. Radiation therapy is to be preferred for this purpose, because of the often severe toxicity that is associated with chemotherapy in infants. One, and possibly two babies in this series died of chemotherapy‐related complications.
KW - hepatomegaly
KW - metastatic neuroblastoma
KW - regression of neuroblastoma
KW - stage IV‐S neuroblastoma
UR - http://www.scopus.com/inward/record.url?scp=0021250821&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021250821&partnerID=8YFLogxK
U2 - 10.1002/mpo.2950120302
DO - 10.1002/mpo.2950120302
M3 - Article
C2 - 6727772
AN - SCOPUS:0021250821
VL - 12
SP - 155
EP - 161
JO - Pediatric Blood and Cancer
JF - Pediatric Blood and Cancer
SN - 1545-5009
IS - 3
ER -