Jack of all trades: Thymosin α1 and its pleiotropy

Luigina Romani, Silvia Moretti, Francesca Fallarino, Silvia Bozza, Loredana Ruggeri, Andrea Casagrande, Franco Aversa, Francesco Bistoni, Andrea Velardi, Enrico Garaci

Research output: Contribution to journalArticlepeer-review

Abstract

Thymosin α1 (Tα1), a thymosin-related 28-mer synthetic amino-terminal acetylated peptide, has gained increasing interest in recent years, due to its pleiotropy. The peptide has been used worldwide as an adjuvant or immunotherapeutic agent to treat disparate human diseases, including viral infections, immunodeficiencies, and malignancies. The peptide can enhance T cell, dendritic cell (DC), and antibody responses, modulate cytokine and chemokine production, and block steroid-induced apoptosis of thymocytes. Its central role in modulating DC function and activating multiple signaling pathways that contribute to different functions may offer a plausible explanation for its pleiotropic action. Additionally, the ability of Tα1 to activate the indoleamine 2,3-dioxygenase enzyme-which confers immune tolerance during transplantation and restrains the vicious circle of chronic inflammation-has been a turning point, suggesting a potential, specific function in immunity. Accordingly, Tα1 has recently been shown to promote immune reconstitution and improve survival of recipients of HLA-matched sibling T cell-depleted stem cell transplants in a phase I/II clinical trial. Thus, Tα1 continues to live up to its promises.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalAnnals of the New York Academy of Sciences
Volume1269
Issue number1
DOIs
Publication statusPublished - Oct 2012

Keywords

  • Hematopoietic transplantation
  • IDO
  • Thymosin α1
  • TLRs
  • Tolerance

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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