TY - JOUR
T1 - JAK3 variant, immune signatures, DNA methylation, and social determinants linked to survival racial disparities in head and neck cancer patients
AU - Guerrero-Preston, Rafael
AU - Lawson, Fahcina
AU - Rodriguez-Torres, Sebastian
AU - Noordhuis, Maartje G.
AU - Pirini, Francesca
AU - Manuel, Laura
AU - Valle, Blanca L.
AU - Hadar, Tal
AU - Rivera, Bianca
AU - Folawiyo, Oluwasina
AU - Baez, Adriana
AU - Marchionni, Luigi
AU - Koch, Wayne M.
AU - Westra, William H.
AU - Kim, Young J.
AU - Eshleman, James R.
AU - Sidransky, David
PY - 2019/4/1
Y1 - 2019/4/1
N2 - To inform novel personalized medicine approaches Analyses also showed differences in the frequency of for race and socioeconomic disparities in head and TP53 mutations (n ¼ 32) and tumor-infiltrating lym-neck cancer, we examined germline and somatic muta-phocyte (TIL) counts (n ¼ 24), and the presence of a tions, immune signatures, and epigenetic alterations specific C ! A germline mutation in JAK3, linked to neighborhood determinants of health in Black chr19:17954215 (protein P132T), in Black patients and non-Latino White (NLW) patients with head and with HNSCC (n ¼ 73; P < 0.05), when compared with neck cancer. Cox proportional hazards revealed that NLW (n ¼ 37) patients. TIL counts are associated (P ¼ Black patients with squamous cell carcinoma of head 0.035) with long-term (>5 years), when compared with and neck (HNSCC) with PAX5 (P ¼ 0.06) and PAX1 short-term survival (<2 years). We show bio-social (P ¼ 0.017) promoter methylation had worse survival determinants of health associated with survival in than NLW patients, after controlling for education, Black patients with HNSCC, which together with racial zipcode, and tumor–node–metastasis stage (n ¼ differences shown in germline mutations, somatic 118). We also found that promoter methylation of mutations, and TIL counts, suggests that contextual PAX1 and PAX5 (n ¼ 78), was correlated with neigh-factors may significantly inform precision oncology borhood characteristics at the zip-code level (P < 0.05). services for diverse populations.
AB - To inform novel personalized medicine approaches Analyses also showed differences in the frequency of for race and socioeconomic disparities in head and TP53 mutations (n ¼ 32) and tumor-infiltrating lym-neck cancer, we examined germline and somatic muta-phocyte (TIL) counts (n ¼ 24), and the presence of a tions, immune signatures, and epigenetic alterations specific C ! A germline mutation in JAK3, linked to neighborhood determinants of health in Black chr19:17954215 (protein P132T), in Black patients and non-Latino White (NLW) patients with head and with HNSCC (n ¼ 73; P < 0.05), when compared with neck cancer. Cox proportional hazards revealed that NLW (n ¼ 37) patients. TIL counts are associated (P ¼ Black patients with squamous cell carcinoma of head 0.035) with long-term (>5 years), when compared with and neck (HNSCC) with PAX5 (P ¼ 0.06) and PAX1 short-term survival (<2 years). We show bio-social (P ¼ 0.017) promoter methylation had worse survival determinants of health associated with survival in than NLW patients, after controlling for education, Black patients with HNSCC, which together with racial zipcode, and tumor–node–metastasis stage (n ¼ differences shown in germline mutations, somatic 118). We also found that promoter methylation of mutations, and TIL counts, suggests that contextual PAX1 and PAX5 (n ¼ 78), was correlated with neigh-factors may significantly inform precision oncology borhood characteristics at the zip-code level (P < 0.05). services for diverse populations.
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U2 - 10.1158/1940-6207.CAPR-17-0356
DO - 10.1158/1940-6207.CAPR-17-0356
M3 - Article
C2 - 30777857
AN - SCOPUS:85064047599
VL - 12
SP - 255
EP - 270
JO - Cancer Prevention Research
JF - Cancer Prevention Research
SN - 1940-6207
IS - 4
ER -