JCV-specific T-cells producing IFN-gamma are differently associated with PML occurrence in HIV patients and liver transplant recipients

Chiara Agrati, Luciano Izzo, Giulia Berno, Eleonora Cimini, Veronica Bordoni, Maria L. Giancola, Francesco Baldini, Marco Colasanti, Giuseppe M. Ettorre, Paolo Izzo, Federico Pugliese, Marco Angrisani, Pierfrancesco Di Cello, Maria R. Capobianchi, Antonio Bolognese

Research output: Contribution to journalArticlepeer-review

Abstract

Aim of this work was to investigate a possible correlation between the frequency of JCV-specific T-cells and PML occurrence in HIV-infected subjects and in liver transplant recipients. A significant decrease of JCV-specific T-cells was observed in HIV-PML subjects, highlighting a close relation between JCV-specific T-cell immune impairment and PML occurrence in HIV-subjects. Interestingly, liver-transplant recipients (LTR) showed a low frequency of JCV-specific T-cells, similar to HIV-PML subjects. Nevertheless, none of the enrolled LTR developed PML, suggesting the existence of different immunological mechanisms involved in the maintenance of a protective immune response in LTR.

Original languageEnglish
Pages (from-to)85-89
Number of pages5
JournalNew Microbiologica
Volume38
Issue number1
Publication statusPublished - Jan 1 2015

Keywords

  • HIV subjects
  • JCV-specific T cells
  • Liver transplant recipients
  • PML

ASJC Scopus subject areas

  • Microbiology (medical)
  • Medicine(all)

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