Abstract
Huntington's disease (HD) is caused by a CAG repeat mutation translating as a polyglutamine (poly(Q)) expansion in the huntingtin protein, whose main pathogenic mechanism is a gain of toxic function. In the case of large expansions beyond 60 repeats onset may result in juvenile HD (JHD, onset before 20 years of age). However, the triplet number does not represent the only onset modifier even in case of large expansions, mechanisms other than the size of the mutation contribute to the phenotype. In this review we discuss the possibility that some of the pathogenic mechanisms contributing to age at onset and progression may differ in the early onset HD compared with the classical adult pathology.
Original language | English |
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Pages (from-to) | 208-212 |
Number of pages | 5 |
Journal | Mechanisms of Ageing and Development |
Volume | 127 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2006 |
Keywords
- Age at onset
- Clinics of juvenile Huntington disease
- Genetics of Huntington disease
- Infantile Huntington disease
- Juvenile Huntington disease
ASJC Scopus subject areas
- Ageing
- Biochemistry
- Developmental Biology
- Developmental Neuroscience