Juvenile stroke and migraine with aura: Evaluation of common risk factors

F. Moschiano, D. D'Amico, M. Leone, C. Ariano, E. Ciusani, N. Elba, F. Schieroni, G. Bussone

Research output: Contribution to journalArticlepeer-review


ABVI: Two groups of young adults with juvenile stroke (JS) or migraine with aura (MA) were studied in order to evaluate the presence and frequency of common risk factors . PATIENTS: 55 subjects of both sexes entered the study, 21 with JS (mean age 40.2; 6 F, 15 M) and 34 affected by MA (mean age 31.3; 24 F, 10 M). METHODS: All patients underwent clinical evaluation, cerebral MR, 2D-echocardiography and blood tests including coagulation parameters. RESULTS: Hypertension, hypercholesterolemia, diabetes mellitus and smoking were more frequent in JS. Anti-phospholipid antibodies (APA) and resistance to activated protein C (APCr) together with the corresponding factor V Leiden mutation (LEI) were present in 19% of JS patients. As far sa MA patients were concerned, 19% had APCr and LEI ; 3% were deficient in protein C and 12% in protein S. DISCUSSION: APCr resistance due to LEI appears as the only common risk factor in JS and MA, showing a similar frequency in both conditions (19%) which is higher than in the general population (2-6%).

Original languageEnglish
Pages (from-to)46
Number of pages1
JournalItalian Journal of Neurological Sciences
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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