K cell activity in ovarian cancer patients given chemotherapy

Alberto Mantovani, Nadia Polentarutti, Patrizia Gritti, Giorgio Bolis, Angelo Maggioni, Federico Spreafico

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

K cell activity was evaluated in 20 patients with advanced ovarian epithelial tumours, using 51Cr-labelled murine lymphoma cells as targets. Cancer patients showed significantly lower K cell activity than 40 sex and age matched controls. Cyclophosphamide, given alone or in combination with adriamycin, did not significantly affect K cell activity per unit number of lymphoid cells, whereas lymphoproliferative responses to phytohaemagglutinin and pokeweed mitogen were markedly suppressed by these agents. Patients showing an objective response to chemotherapy had K cell activity values similar to non responders.

Original languageEnglish
Pages (from-to)797-802
Number of pages6
JournalEuropean Journal of Cancer (1965)
Volume15
Issue number5
DOIs
Publication statusPublished - 1979

Fingerprint

Ovarian Neoplasms
Drug Therapy
Pokeweed Mitogens
Phytohemagglutinins
Doxorubicin
Cyclophosphamide
Lymphoma
Neoplasms
Lymphocytes

ASJC Scopus subject areas

  • Oncology

Cite this

K cell activity in ovarian cancer patients given chemotherapy. / Mantovani, Alberto; Polentarutti, Nadia; Gritti, Patrizia; Bolis, Giorgio; Maggioni, Angelo; Spreafico, Federico.

In: European Journal of Cancer (1965), Vol. 15, No. 5, 1979, p. 797-802.

Research output: Contribution to journalArticle

Mantovani, Alberto ; Polentarutti, Nadia ; Gritti, Patrizia ; Bolis, Giorgio ; Maggioni, Angelo ; Spreafico, Federico. / K cell activity in ovarian cancer patients given chemotherapy. In: European Journal of Cancer (1965). 1979 ; Vol. 15, No. 5. pp. 797-802.
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