K cell activity was evaluated in 20 patients with advanced ovarian epithelial tumours, using 51Cr-labelled murine lymphoma cells as targets. Cancer patients showed significantly lower K cell activity than 40 sex and age matched controls. Cyclophosphamide, given alone or in combination with adriamycin, did not significantly affect K cell activity per unit number of lymphoid cells, whereas lymphoproliferative responses to phytohaemagglutinin and pokeweed mitogen were markedly suppressed by these agents. Patients showing an objective response to chemotherapy had K cell activity values similar to non responders.
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