Kaposi's sarcoma following malignant mesothelioma

Valeria Ascoli, Caterina Carnovale Scalzo, Massimo Andreoni, Liborio Manente, Alessandra Pistilli, Francesco Lo Coco

Research output: Contribution to journalArticlepeer-review

Abstract

We report the unusual occurrence of Kaposi's sarcoma following asbestos-related malignant mesothelioma, in a human deficiency virus (HIV)-negative Italian man. Seropositivity to human herpes virus 8 (HHV8) was documented at the time of mesothelioma diagnosis and preceded the onset of Kaposi' sarcoma with a time lapse of 13 months. HHV8 DNA was detected by polymerase chain reaction in lesional Kaposi's sarcoma but not within mesothelioma. By immunostaining, mesothelioma cells expressed interleukin-6 and platelet-derived growth factor, which are important for survival of Kaposi's sarcoma cells. Besides the possibility of a casual association, we hypothesize that mesothelioma-linked factors may have contributed to the development of Kaposi'sarcoma in the presence of HHV8 infection.

Original languageEnglish
Pages (from-to)612-615
Number of pages4
JournalVirchows Archiv
Volume435
Issue number6
Publication statusPublished - 1999

Keywords

  • Herpes virus
  • Interleukin-6
  • Kaposi sarcoma
  • Kaposi-sarcoma associated
  • Mesothelioma
  • Platelet-derived growth factor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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