TY - JOUR
T1 - Karyotype evolution in a patient with biphenotypic neonatal leukemia
AU - Fugazza, Giusy
AU - Basso, Giuseppe
AU - Sessarego, Mario
AU - Haupt, Riccardo
AU - Comelli, Adele
AU - Roncella, Silvio
AU - Negri, Danilo
AU - Sansone, Raffaele
PY - 1992
Y1 - 1992
N2 - We present the case of a 4-day-old boy with acute lymphoblastic leukemia showing at onset a karyotype 46,XY,t(4;11)(q21;q23). At relapse an additional change, add(2), was present. Molecular analysis showed the same immunoglobulin rearrangement both at onset and at relapse, but immunohistochemical analysis revealed some cells having myeloid features. A continuous cell line derived from the leukemic blasts of the patient presented typical monoblastic features.
AB - We present the case of a 4-day-old boy with acute lymphoblastic leukemia showing at onset a karyotype 46,XY,t(4;11)(q21;q23). At relapse an additional change, add(2), was present. Molecular analysis showed the same immunoglobulin rearrangement both at onset and at relapse, but immunohistochemical analysis revealed some cells having myeloid features. A continuous cell line derived from the leukemic blasts of the patient presented typical monoblastic features.
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U2 - 10.1016/0165-4608(92)90249-8
DO - 10.1016/0165-4608(92)90249-8
M3 - Article
C2 - 1394096
AN - SCOPUS:0026480675
VL - 62
SP - 124
EP - 129
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 2
ER -