Karyotype evolution in a patient with biphenotypic neonatal leukemia

Giusy Fugazza; Giuseppe Basso; Mario Sessarego; Riccardo Haupt; Adele Comelli; Silvio Roncella; Danilo Negri; Raffaele Sansone

doi:10.1016/0165-4608(92)90249-8

Karyotype evolution in a patient with biphenotypic neonatal leukemia

Giusy Fugazza, Giuseppe Basso, Mario Sessarego, Riccardo Haupt, Adele Comelli, Silvio Roncella, Danilo Negri, Raffaele Sansone

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

We present the case of a 4-day-old boy with acute lymphoblastic leukemia showing at onset a karyotype 46,XY,t(4;11)(q21;q23). At relapse an additional change, add(2), was present. Molecular analysis showed the same immunoglobulin rearrangement both at onset and at relapse, but immunohistochemical analysis revealed some cells having myeloid features. A continuous cell line derived from the leukemic blasts of the patient presented typical monoblastic features.

Original language	English
Pages (from-to)	124-129
Number of pages	6
Journal	Cancer Genetics and Cytogenetics
Volume	62
Issue number	2
DOIs	https://doi.org/10.1016/0165-4608(92)90249-8
Publication status	Published - 1992

ASJC Scopus subject areas

Cancer Research
Genetics
Molecular Biology

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abstract = "We present the case of a 4-day-old boy with acute lymphoblastic leukemia showing at onset a karyotype 46,XY,t(4;11)(q21;q23). At relapse an additional change, add(2), was present. Molecular analysis showed the same immunoglobulin rearrangement both at onset and at relapse, but immunohistochemical analysis revealed some cells having myeloid features. A continuous cell line derived from the leukemic blasts of the patient presented typical monoblastic features.",

author = "Giusy Fugazza and Giuseppe Basso and Mario Sessarego and Riccardo Haupt and Adele Comelli and Silvio Roncella and Danilo Negri and Raffaele Sansone",

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AU - Fugazza, Giusy

AU - Basso, Giuseppe

AU - Sessarego, Mario

AU - Haupt, Riccardo

AU - Comelli, Adele

AU - Roncella, Silvio

AU - Negri, Danilo

AU - Sansone, Raffaele

PY - 1992

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N2 - We present the case of a 4-day-old boy with acute lymphoblastic leukemia showing at onset a karyotype 46,XY,t(4;11)(q21;q23). At relapse an additional change, add(2), was present. Molecular analysis showed the same immunoglobulin rearrangement both at onset and at relapse, but immunohistochemical analysis revealed some cells having myeloid features. A continuous cell line derived from the leukemic blasts of the patient presented typical monoblastic features.

AB - We present the case of a 4-day-old boy with acute lymphoblastic leukemia showing at onset a karyotype 46,XY,t(4;11)(q21;q23). At relapse an additional change, add(2), was present. Molecular analysis showed the same immunoglobulin rearrangement both at onset and at relapse, but immunohistochemical analysis revealed some cells having myeloid features. A continuous cell line derived from the leukemic blasts of the patient presented typical monoblastic features.

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