Karyotype evolution in a patient with biphenotypic neonatal leukemia

Giusy Fugazza, Giuseppe Basso, Mario Sessarego, Riccardo Haupt, Adele Comelli, Silvio Roncella, Danilo Negri, Raffaele Sansone

Research output: Contribution to journalArticlepeer-review


We present the case of a 4-day-old boy with acute lymphoblastic leukemia showing at onset a karyotype 46,XY,t(4;11)(q21;q23). At relapse an additional change, add(2), was present. Molecular analysis showed the same immunoglobulin rearrangement both at onset and at relapse, but immunohistochemical analysis revealed some cells having myeloid features. A continuous cell line derived from the leukemic blasts of the patient presented typical monoblastic features.

Original languageEnglish
Pages (from-to)124-129
Number of pages6
JournalCancer Genetics and Cytogenetics
Issue number2
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology


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