Karyotype in acute mybloblastic leukemia (AML): Prognostic significance in bone marrow transplantation in first remission (CR1) a study from Ike scttt leukemia working-party of the European Cooperative Group foe Bknd and Marrow Transplanlaobi (EBMT) NC

Forin M. Labonin, F. Frassoni, H. G. Prenitice, J. Y. Caba, J. Reiffers, M. Boogaerts, G. Bandini, B. Lowernberg, M. Attal, A. Ferrant

Research output: Contribution to journalArticlepeer-review

Abstract

The cylojoielic due of 999 AML pitocs who lud BMT in CR1 hive been ulysed. The karyotypes atiu45), K1S;17) (n-80), 1(831) (->). Ita 5 nd/oi 7 (..50). bu llq (.-33), pieudodkiloid (n.72), hypodiploid (1.24), hyperdipbid (nrf6), or diploU (n-bi llq. pnudodinloidy, hyperdiploidy or with normal kuyotype did not differ. This group of pUieMa hid bead survivil, rorutlil dunliog nd kukemil free survival (LFS) probability than the group of patients with abn 5 and/or 7 or hypodiptady (survival: 0.54 vs 0.23, p-0.00005; remisaioB duration: 0.62 vs 0.21, p-0-000001; LPS: 0.50 vs 0.17,p-0.000008). The outcomes of AUoBMT and ABMT patients with unfavorable cylogenetics were simuar. When conparkl AUoBMT and ABMT in patients with favorable cytogenelio, AUoBMT was of benefit for remisBR duration (p

Original languageEnglish
Pages (from-to)1124
Number of pages1
JournalExperimental Hematology
Volume24
Issue number9
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Genetics
  • Hematology
  • Oncology
  • Transplantation

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