Keap1/Nrf2 impairing revised: Are we missing the single nucleotide polymorphisms?

TY - JOUR

T1 - Keap1/Nrf2 impairing revised: Are we missing the single nucleotide polymorphisms?

AU - Muscarella, L.A.

AU - Fazio, V.M.

N1 - Export Date: 22 March 2017 Correspondence Address: Muscarella, L.A.; Laboratory of Oncology, IRCCS Casa Sollievo della SofferenzaItaly; email: l.muscarella@operapadrepio.it Funding details: 12983, AIRC, Associazione Italiana per la Ricerca sul Cancro Funding text: Funding: This work was supported by the AIRC/MFAG grant 12983 (to LA Muscarella). References: Brigelius-Flohé, R., Flohé, L., Basic principles and emerging concepts in the redox control of transcription factors (2011) Antioxid Redox Signal, 15, pp. 2335-2381; Sporn, M.B., Liby, K.T., NRF2 and cancer: the good, the bad and the importance of context (2012) Nat Rev Cancer, 12, pp. 564-571; Tian, H., Zhang, B., Di, J., Keap1: one stone kills three birds Nrf2, IKKß and Bcl-2/Bcl-xL (2012) Cancer Lett, 325, pp. 26-34; Menegon, S., Columbano, A., Giordano, S., The Dual Roles of NRF2 in Cancer (2016) Trends Mol Med, 22, pp. 578-593; Bai, X., Chen, Y., Hou, X., Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters (2016) Drug Metab Rev, 48, pp. 541-567; Leinonen, H.M., Kansanen, E., Pölönen, P., Role of the Keap1-Nrf2 pathway in cancer (2014) Adv Cancer Res, 122, pp. 281-320; Guo, Y., Yu, S., Zhang, C., Epigenetic regulation of Keap1-Nrf2 signaling (2015) Free Radic Biol Med, 88, pp. 337-349; Hayes, J.D., McMahon, M., NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer (2009) Trends Biochem Sci, 34, pp. 176-188; Barbano, R., Muscarella, L.A., Pasculli, B., Aberrant Keap1 methylation in breast cancer and association with clinicopathological features (2013) Epigenetics, 8, pp. 105-112; Muscarella, L.A., Parrella, P., D'Alessandro, V., Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer (2011) Epigenetics, 6, pp. 710-719; Muscarella, L.A., Barbano, R., D'Angelo, V., Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome (2011) Epigenetics, 6, pp. 317-325; Cowper-Sal Lari, R., Zhang, X., Wright, J.B., Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression (2012) Nat Genet, 44, pp. 1191-1198; Nicoloso, M.S., Sun, H., Spizzo, R., Single-nucleotide polymorphisms inside microRNA target sites influence tumor susceptibility (2010) Cancer Res, 70, pp. 2789-2798; Zhao, N., Han, J.G., Shyu, C.R., Determining effects of non-synonymous SNPs on protein-protein interactions using supervised and semi-supervised learning (2014) PLoS Comput Biol, 10; Hartikainen, J.M., Tengström, M., Winqvist, R., KEAP1 Genetic Polymorphisms Associate with Breast Cancer Risk and Survival Outcomes (2015) Clin Cancer Res, 21, pp. 1591-1601; Eades, G., Yao, Y., Yang, M., miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells (2011) J Biol Chem, 286, pp. 25992-26002; Eades, G., Yang, M., Yao, Y., miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells (2011) J Biol Chem, 286, pp. 40725-40733

PY - 2016

Y1 - 2016

M3 - Article

VL - 8

SP - E1752-E1754

JO - Journal of Thoracic Disease

JF - Journal of Thoracic Disease

SN - 2072-1439

IS - 12

ER -