Keeping memory for intentions: A cTBS investigation of the frontopolar cortex

Alberto Costa, Massimiliano Oliveri, Francesco Barban, Sara Torriero, Silvia Salerno, Emanuele Lo Gerfo, Giacomo Koch, Carlo Caltagirone, Giovanni Augusto Carlesimo

Research output: Contribution to journalArticle

Abstract

The present study aimed to investigate the role of frontopolar cortex in prospective memory (PM) by means of inhibitory theta-burst stimulation (cTBS). Experiment 1-8 volunteers were evaluated after inhibitory cTBS over left Brodmann area (BA) 10, right BA10, and Cz. In the PM procedure, sequences of 4 words each were presented. During the intersequence delay, subjects had to repeat the sequence in the observed order (ongoing task forward) or in the reverse order (backward). At the occurrence of a target word, subjects had to press a key on the keyboard (PM task). Recall and recognition of the target words were also tested. PM accuracy was lower after cTBS over left BA10 compared with Cz (P = 0.012), whereas it was comparable in right BA10 and Cz conditions. No other significant differences between the 3 conditions were found. Experiment 2-8 subjects were administered the same experimental PM procedure as above after inhibitory cTBS over left BA46 and Cz. In this case, none of the tested effects were significant. Our findings corroborate the hypothesis that within the prefrontal cortex, the left BA10 is specifically involved in the mediation of processes related to the execution of delayed intentions.

Original languageEnglish
Pages (from-to)2696-2703
Number of pages8
JournalCerebral Cortex
Volume21
Issue number12
DOIs
Publication statusPublished - Dec 2011

Fingerprint

Episodic Memory
Prefrontal Cortex
Volunteers

Keywords

  • Brodmann area 10
  • delayed intentions
  • prefrontal regions
  • prospective remembering
  • transcranial magnetic stimulation

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Keeping memory for intentions : A cTBS investigation of the frontopolar cortex. / Costa, Alberto; Oliveri, Massimiliano; Barban, Francesco; Torriero, Sara; Salerno, Silvia; Lo Gerfo, Emanuele; Koch, Giacomo; Caltagirone, Carlo; Carlesimo, Giovanni Augusto.

In: Cerebral Cortex, Vol. 21, No. 12, 12.2011, p. 2696-2703.

Research output: Contribution to journalArticle

Costa A, Oliveri M, Barban F, Torriero S, Salerno S, Lo Gerfo E et al. Keeping memory for intentions: A cTBS investigation of the frontopolar cortex. Cerebral Cortex. 2011 Dec;21(12):2696-2703. https://doi.org/10.1093/cercor/bhr052
Costa, Alberto ; Oliveri, Massimiliano ; Barban, Francesco ; Torriero, Sara ; Salerno, Silvia ; Lo Gerfo, Emanuele ; Koch, Giacomo ; Caltagirone, Carlo ; Carlesimo, Giovanni Augusto. / Keeping memory for intentions : A cTBS investigation of the frontopolar cortex. In: Cerebral Cortex. 2011 ; Vol. 21, No. 12. pp. 2696-2703.
@article{82c3bc34818f4e2f897a646e5cc44034,
title = "Keeping memory for intentions: A cTBS investigation of the frontopolar cortex",
abstract = "The present study aimed to investigate the role of frontopolar cortex in prospective memory (PM) by means of inhibitory theta-burst stimulation (cTBS). Experiment 1-8 volunteers were evaluated after inhibitory cTBS over left Brodmann area (BA) 10, right BA10, and Cz. In the PM procedure, sequences of 4 words each were presented. During the intersequence delay, subjects had to repeat the sequence in the observed order (ongoing task forward) or in the reverse order (backward). At the occurrence of a target word, subjects had to press a key on the keyboard (PM task). Recall and recognition of the target words were also tested. PM accuracy was lower after cTBS over left BA10 compared with Cz (P = 0.012), whereas it was comparable in right BA10 and Cz conditions. No other significant differences between the 3 conditions were found. Experiment 2-8 subjects were administered the same experimental PM procedure as above after inhibitory cTBS over left BA46 and Cz. In this case, none of the tested effects were significant. Our findings corroborate the hypothesis that within the prefrontal cortex, the left BA10 is specifically involved in the mediation of processes related to the execution of delayed intentions.",
keywords = "Brodmann area 10, delayed intentions, prefrontal regions, prospective remembering, transcranial magnetic stimulation",
author = "Alberto Costa and Massimiliano Oliveri and Francesco Barban and Sara Torriero and Silvia Salerno and {Lo Gerfo}, Emanuele and Giacomo Koch and Carlo Caltagirone and Carlesimo, {Giovanni Augusto}",
year = "2011",
month = "12",
doi = "10.1093/cercor/bhr052",
language = "English",
volume = "21",
pages = "2696--2703",
journal = "Cerebral Cortex",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "12",

}

TY - JOUR

T1 - Keeping memory for intentions

T2 - A cTBS investigation of the frontopolar cortex

AU - Costa, Alberto

AU - Oliveri, Massimiliano

AU - Barban, Francesco

AU - Torriero, Sara

AU - Salerno, Silvia

AU - Lo Gerfo, Emanuele

AU - Koch, Giacomo

AU - Caltagirone, Carlo

AU - Carlesimo, Giovanni Augusto

PY - 2011/12

Y1 - 2011/12

N2 - The present study aimed to investigate the role of frontopolar cortex in prospective memory (PM) by means of inhibitory theta-burst stimulation (cTBS). Experiment 1-8 volunteers were evaluated after inhibitory cTBS over left Brodmann area (BA) 10, right BA10, and Cz. In the PM procedure, sequences of 4 words each were presented. During the intersequence delay, subjects had to repeat the sequence in the observed order (ongoing task forward) or in the reverse order (backward). At the occurrence of a target word, subjects had to press a key on the keyboard (PM task). Recall and recognition of the target words were also tested. PM accuracy was lower after cTBS over left BA10 compared with Cz (P = 0.012), whereas it was comparable in right BA10 and Cz conditions. No other significant differences between the 3 conditions were found. Experiment 2-8 subjects were administered the same experimental PM procedure as above after inhibitory cTBS over left BA46 and Cz. In this case, none of the tested effects were significant. Our findings corroborate the hypothesis that within the prefrontal cortex, the left BA10 is specifically involved in the mediation of processes related to the execution of delayed intentions.

AB - The present study aimed to investigate the role of frontopolar cortex in prospective memory (PM) by means of inhibitory theta-burst stimulation (cTBS). Experiment 1-8 volunteers were evaluated after inhibitory cTBS over left Brodmann area (BA) 10, right BA10, and Cz. In the PM procedure, sequences of 4 words each were presented. During the intersequence delay, subjects had to repeat the sequence in the observed order (ongoing task forward) or in the reverse order (backward). At the occurrence of a target word, subjects had to press a key on the keyboard (PM task). Recall and recognition of the target words were also tested. PM accuracy was lower after cTBS over left BA10 compared with Cz (P = 0.012), whereas it was comparable in right BA10 and Cz conditions. No other significant differences between the 3 conditions were found. Experiment 2-8 subjects were administered the same experimental PM procedure as above after inhibitory cTBS over left BA46 and Cz. In this case, none of the tested effects were significant. Our findings corroborate the hypothesis that within the prefrontal cortex, the left BA10 is specifically involved in the mediation of processes related to the execution of delayed intentions.

KW - Brodmann area 10

KW - delayed intentions

KW - prefrontal regions

KW - prospective remembering

KW - transcranial magnetic stimulation

UR - http://www.scopus.com/inward/record.url?scp=79959355624&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959355624&partnerID=8YFLogxK

U2 - 10.1093/cercor/bhr052

DO - 10.1093/cercor/bhr052

M3 - Article

C2 - 21515712

AN - SCOPUS:79959355624

VL - 21

SP - 2696

EP - 2703

JO - Cerebral Cortex

JF - Cerebral Cortex

SN - 1047-3211

IS - 12

ER -