La dieta chetogena nelle epilessie farmacoresistenti

Translated title of the contribution: Ketogenic diet in farmacoresistant epilepsies

R. Cusmai, M. L. Lispi, M. Elia, C. Dionisi, C. Rizzo, P. Veggiotti, C. Resi, S. Cardinali, S. Bertoli, A. Tagliabue, C. Trentani, E. Lanzola, G. Lanzi, G. Coppola, I. Distinto, N. Sciscio, A. Pascotto

Research output: Contribution to journalArticlepeer-review


In this collaborative trial from three italian groups of Child Neuropsychiatry, classical (4:1) ketogenic diet has been evalued as add-on treatment in 41 refractory epilepsy patients, aged 1-18 years. Diagnoses were: partial or generalized crypto/symptomatic epilepsy, severe myoclonic epilepsy in infancy and ESES. Child neuropsychiatrists collaborated with dieticians to carry out sample's selection and patient'management. During treatment, seizure frequency, side effects, ketonuria, blood ketone levels and other parameters were evalued. A seizure decrease of more than 50% was obtained in 31% of patients at three months from starting diet: 6 (symptomatic partial epilepsies), 1 (cryptogenic partial epilepsy), 6 (generalized symptomatic epilepsies) one (cryptogenic generalized epilepsy). One year follow up showed only three responders (7%). It is noteworth that the predominant epilepsy etiology of responders was hypoxic-ischaemic insult, in partial epilepsies, and disorder of migration (pachygyria) in generalizd epilepsies.

Translated title of the contributionKetogenic diet in farmacoresistant epilepsies
Original languageItalian
Pages (from-to)365-367
Number of pages3
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number106-107
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Clinical Neurology


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