TY - JOUR
T1 - La dieta chetogena nelle epilessie farmacoresistenti
AU - Cusmai, R.
AU - Lispi, M. L.
AU - Elia, M.
AU - Dionisi, C.
AU - Rizzo, C.
AU - Veggiotti, P.
AU - Resi, C.
AU - Cardinali, S.
AU - Bertoli, S.
AU - Tagliabue, A.
AU - Trentani, C.
AU - Lanzola, E.
AU - Lanzi, G.
AU - Coppola, G.
AU - Distinto, I.
AU - Sciscio, N.
AU - Pascotto, A.
PY - 1999
Y1 - 1999
N2 - In this collaborative trial from three italian groups of Child Neuropsychiatry, classical (4:1) ketogenic diet has been evalued as add-on treatment in 41 refractory epilepsy patients, aged 1-18 years. Diagnoses were: partial or generalized crypto/symptomatic epilepsy, severe myoclonic epilepsy in infancy and ESES. Child neuropsychiatrists collaborated with dieticians to carry out sample's selection and patient'management. During treatment, seizure frequency, side effects, ketonuria, blood ketone levels and other parameters were evalued. A seizure decrease of more than 50% was obtained in 31% of patients at three months from starting diet: 6 (symptomatic partial epilepsies), 1 (cryptogenic partial epilepsy), 6 (generalized symptomatic epilepsies) one (cryptogenic generalized epilepsy). One year follow up showed only three responders (7%). It is noteworth that the predominant epilepsy etiology of responders was hypoxic-ischaemic insult, in partial epilepsies, and disorder of migration (pachygyria) in generalizd epilepsies.
AB - In this collaborative trial from three italian groups of Child Neuropsychiatry, classical (4:1) ketogenic diet has been evalued as add-on treatment in 41 refractory epilepsy patients, aged 1-18 years. Diagnoses were: partial or generalized crypto/symptomatic epilepsy, severe myoclonic epilepsy in infancy and ESES. Child neuropsychiatrists collaborated with dieticians to carry out sample's selection and patient'management. During treatment, seizure frequency, side effects, ketonuria, blood ketone levels and other parameters were evalued. A seizure decrease of more than 50% was obtained in 31% of patients at three months from starting diet: 6 (symptomatic partial epilepsies), 1 (cryptogenic partial epilepsy), 6 (generalized symptomatic epilepsies) one (cryptogenic generalized epilepsy). One year follow up showed only three responders (7%). It is noteworth that the predominant epilepsy etiology of responders was hypoxic-ischaemic insult, in partial epilepsies, and disorder of migration (pachygyria) in generalizd epilepsies.
KW - Alternative Therapy
KW - Epilepsy
KW - Ketogenic diet
UR - http://www.scopus.com/inward/record.url?scp=0033507008&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033507008&partnerID=8YFLogxK
M3 - Articolo
AN - SCOPUS:0033507008
SP - 365
EP - 367
JO - Bollettino - Lega Italiana contro l'Epilessia
JF - Bollettino - Lega Italiana contro l'Epilessia
SN - 0394-560X
IS - 106-107
ER -