TY - JOUR
T1 - Ketogenic diet in migraine
T2 - rationale, findings and perspectives
AU - Barbanti, Piero
AU - Fofi, Luisa
AU - Aurilia, Cinzia
AU - Egeo, Gabriella
AU - Caprio, Massimiliano
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Ketogenic diet (KD) is an established treatment for refractory pediatric epilepsy and a promising therapy for diverse neurological diseases. Clinical data on KD in migraine—obtained from 150 patients investigated in case reports and prospective studies—suggest that KD may be a rapid onset effective prophylaxis for episodic and chronic migraine. KD would contribute to restore brain excitability and metabolism and to counteract neuroinflammation in migraine, although its precise mechanism is still unclear. Randomized controlled studies are needed to confirm the usefulness of KD in migraine and to investigate its optimal duration, repeatability, feasibility in normal weight subjects, efficacy in pediatric population and association to conventional migraine prophylaxis.
AB - Ketogenic diet (KD) is an established treatment for refractory pediatric epilepsy and a promising therapy for diverse neurological diseases. Clinical data on KD in migraine—obtained from 150 patients investigated in case reports and prospective studies—suggest that KD may be a rapid onset effective prophylaxis for episodic and chronic migraine. KD would contribute to restore brain excitability and metabolism and to counteract neuroinflammation in migraine, although its precise mechanism is still unclear. Randomized controlled studies are needed to confirm the usefulness of KD in migraine and to investigate its optimal duration, repeatability, feasibility in normal weight subjects, efficacy in pediatric population and association to conventional migraine prophylaxis.
KW - Disability
KW - Ketogenic diet
KW - Migraine
KW - Prevention
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=85019629200&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019629200&partnerID=8YFLogxK
U2 - 10.1007/s10072-017-2889-6
DO - 10.1007/s10072-017-2889-6
M3 - Article
AN - SCOPUS:85019629200
VL - 38
SP - 111
EP - 115
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
ER -