Ketogenic diet in pharmacoresistant epilepsies

R. Cusmai, C. Dionisi, C. Rizzo, M. Elia, M. L. Lispi, G. Coppohr, I. Distintcr, N. Scisciîr, A. Pascotur, P. Veggiotli', C. Resi', S. Cardinal, S. Bertoli, A. Tagliabue, C. Trentani, E. Lanzola, G. Lanzi'

Research output: Contribution to journalArticle


In this collaborative trial from three Italian groups of child neuropsychiatry, classic (4:1 ) ketogenic diet has been evaluated as add-on treatment in 41 refractory epilepsy patients, aged 1-18 years. Diagnoses were: partial or generalized crypto/symptomatic epilepsy, severe myoclonic epilepsy in infancy and ESES. Child neuropsychiatrists collaborated with dieticians to carry out sample selection and patient management. During treatment, seizure frequency, side effects, ketonuria, blood ketone levels and other parameters were evaluated. A seizure decrease of more than 50% was obtained in 31 % of patients at three months from starting diet: 6 (symptomatic partial epilepsies), I (cryptogenic partial epilepsy), 6 (generalized symptomatic epilepsies), and 1 (cryptogenic generalized epilepsy). One year follow-up showed only three responders (?%). It is noteworthy that the predominant epilepsy etiology of responders was hypoxic-ischemic insult, in partial epilepsies, and disorder of migration (pachygyria) in generalized epilepsies.

Original languageEnglish
Pages (from-to)358
Number of pages1
JournalItalian Journal of Neurological Sciences
Issue number5
Publication statusPublished - 1999


ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Cusmai, R., Dionisi, C., Rizzo, C., Elia, M., Lispi, M. L., Coppohr, G., Distintcr, I., Scisciîr, N., Pascotur, A., Veggiotli', P., Resi', C., Cardinal, S., Bertoli, S., Tagliabue, A., Trentani, C., Lanzola, E., & Lanzi', G. (1999). Ketogenic diet in pharmacoresistant epilepsies. Italian Journal of Neurological Sciences, 20(5), 358.