Ketogenic diet use in children with intractable epilepsy secondary to malformations of cortical development: A two- centre experience

Ludovica Pasca, Roberto H. Caraballo, Valentina De Giorgis, J. Gabriela Reyes, Joyce A. Macasaet, Silvia Masnada, Marisa Armeno, Massimo Musicco, Anna Tagliabue, Pierangelo Veggiotti

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To evaluate the efficacy and tolerability of the ketogenic diet (KD) as a treatment for drug-resistant epilepsy secondary to malformations of cortical development. Methods: A two-centre retrospective analysis of 45 paediatric patients with refractory epilepsy due to malformation of cortical development was carried out. Patients were divided into three groups based on malformation type: abnormal neural proliferation (Group 1); abnormal neural migration (Group 2) and abnormal post-migrational development (Group 3). The efficacy of the KD was assessed in terms of seizure frequency reduction. We identified the proportion of patients achieving > 50% seizure frequency reduction overall and in the three subgroups. Results: The adherence to KD was variable. KD was pursued from a minimum of 4 months to a maximum of 96 months. 20 patients (44%) obtained a seizure reduction of > 50% and 2 patients became seizure free. >50% seizure reduction was most commonly achieved by patients in group 3 (64.7%) than in groups 2 (31.8%) and 1 (33.3%). Conclusions: The best response was observed in patients with malformations of post migrational development. Considering its tolerability, the use of KD should be considered in patients with drug-resistant epilepsy secondary to malformations of cortical development when surgery is not a viable option.

Original languageEnglish
Pages (from-to)34-37
Number of pages4
JournalSeizure
Volume57
DOIs
Publication statusPublished - Apr 1 2018

Keywords

  • Cortical malformation
  • Drug resistant epilepsy
  • ESES
  • Ketogenic diet
  • Pediatric
  • Polymicrogyria
  • Seizure freedom
  • Tolerability

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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