Abstract
Immobilization and the consequent unloading can cause osteopenia both in humans and in animals due to an increased bone resorption and a parallel reduction in bone formation. Nonsteroidal anti-inflammatory drugs (NSAIDs), and in particular the aryl propionic acids, are described to prevent bone loss by inhibiting the cyclo-oxygenase activity. In this study we evaluated the role of a classical aryl propionic acid, ketoprofen lysine salt (KLS), in a new model of disuse-induced osteoporosis in the rat. Tail immobilization evoked a time-dependent bone loss in the caudal vertebral bodies, measured densitometrically as a reduction of bone mineral density (BMD) and content (BMC). KLS was administered once daily for 10 days by subcutaneous route at 0.5 mg kg-1, a dose lower than that effective to elicit an anti-inflammatory response. In these conditions, KLS completely abolished BMD and BMC decrease observed in the caudal vertebrae after 10-day immobilization, without affecting bone mass in normal (non-immobilized) rats. These results suggest that KLS can exert, besides to its anti-inflammatory effect, an anti-resorptive activity on bone that could be useful in the prevention of disuse-induced osteopenia.
| Original language | English |
|---|---|
| Pages (from-to) | 277-281 |
| Number of pages | 5 |
| Journal | Pharmacological Research |
| Volume | 33 |
| Issue number | 4-5 |
| DOIs | |
| Publication status | Published - Apr 1996 |
Fingerprint
Keywords
- Bone metabolism
- Immobilization
- Ketoprofen lysine salt
- Osteopenia
ASJC Scopus subject areas
- Pharmacology
Cite this
Ketoprofen lysine salt inhibits disuse-induced osteopenia in a new non-traumatic immobilization model in the rat. / Fiorentino, S.; Melillo, G.; Fedele, G.; Clavenna, G.; D'Agostino, C.; Mainetti, E.; Caselli, G. F.
In: Pharmacological Research, Vol. 33, No. 4-5, 04.1996, p. 277-281.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ketoprofen lysine salt inhibits disuse-induced osteopenia in a new non-traumatic immobilization model in the rat
AU - Fiorentino, S.
AU - Melillo, G.
AU - Fedele, G.
AU - Clavenna, G.
AU - D'Agostino, C.
AU - Mainetti, E.
AU - Caselli, G. F.
PY - 1996/4
Y1 - 1996/4
N2 - Immobilization and the consequent unloading can cause osteopenia both in humans and in animals due to an increased bone resorption and a parallel reduction in bone formation. Nonsteroidal anti-inflammatory drugs (NSAIDs), and in particular the aryl propionic acids, are described to prevent bone loss by inhibiting the cyclo-oxygenase activity. In this study we evaluated the role of a classical aryl propionic acid, ketoprofen lysine salt (KLS), in a new model of disuse-induced osteoporosis in the rat. Tail immobilization evoked a time-dependent bone loss in the caudal vertebral bodies, measured densitometrically as a reduction of bone mineral density (BMD) and content (BMC). KLS was administered once daily for 10 days by subcutaneous route at 0.5 mg kg-1, a dose lower than that effective to elicit an anti-inflammatory response. In these conditions, KLS completely abolished BMD and BMC decrease observed in the caudal vertebrae after 10-day immobilization, without affecting bone mass in normal (non-immobilized) rats. These results suggest that KLS can exert, besides to its anti-inflammatory effect, an anti-resorptive activity on bone that could be useful in the prevention of disuse-induced osteopenia.
AB - Immobilization and the consequent unloading can cause osteopenia both in humans and in animals due to an increased bone resorption and a parallel reduction in bone formation. Nonsteroidal anti-inflammatory drugs (NSAIDs), and in particular the aryl propionic acids, are described to prevent bone loss by inhibiting the cyclo-oxygenase activity. In this study we evaluated the role of a classical aryl propionic acid, ketoprofen lysine salt (KLS), in a new model of disuse-induced osteoporosis in the rat. Tail immobilization evoked a time-dependent bone loss in the caudal vertebral bodies, measured densitometrically as a reduction of bone mineral density (BMD) and content (BMC). KLS was administered once daily for 10 days by subcutaneous route at 0.5 mg kg-1, a dose lower than that effective to elicit an anti-inflammatory response. In these conditions, KLS completely abolished BMD and BMC decrease observed in the caudal vertebrae after 10-day immobilization, without affecting bone mass in normal (non-immobilized) rats. These results suggest that KLS can exert, besides to its anti-inflammatory effect, an anti-resorptive activity on bone that could be useful in the prevention of disuse-induced osteopenia.
KW - Bone metabolism
KW - Immobilization
KW - Ketoprofen lysine salt
KW - Osteopenia
UR - http://www.scopus.com/inward/record.url?scp=0030130586&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030130586&partnerID=8YFLogxK
U2 - 10.1006/phrs.1996.0039
DO - 10.1006/phrs.1996.0039
M3 - Article
C2 - 8938021
AN - SCOPUS:0030130586
VL - 33
SP - 277
EP - 281
JO - Pharmacological Research
JF - Pharmacological Research
SN - 1043-6618
IS - 4-5
ER -