Ketoprofen lysine salt inhibits disuse-induced osteopenia in a new non-traumatic immobilization model in the rat

S. Fiorentino, G. Melillo, G. Fedele, G. Clavenna, C. D'Agostino, E. Mainetti, G. F. Caselli

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Immobilization and the consequent unloading can cause osteopenia both in humans and in animals due to an increased bone resorption and a parallel reduction in bone formation. Nonsteroidal anti-inflammatory drugs (NSAIDs), and in particular the aryl propionic acids, are described to prevent bone loss by inhibiting the cyclo-oxygenase activity. In this study we evaluated the role of a classical aryl propionic acid, ketoprofen lysine salt (KLS), in a new model of disuse-induced osteoporosis in the rat. Tail immobilization evoked a time-dependent bone loss in the caudal vertebral bodies, measured densitometrically as a reduction of bone mineral density (BMD) and content (BMC). KLS was administered once daily for 10 days by subcutaneous route at 0.5 mg kg-1, a dose lower than that effective to elicit an anti-inflammatory response. In these conditions, KLS completely abolished BMD and BMC decrease observed in the caudal vertebrae after 10-day immobilization, without affecting bone mass in normal (non-immobilized) rats. These results suggest that KLS can exert, besides to its anti-inflammatory effect, an anti-resorptive activity on bone that could be useful in the prevention of disuse-induced osteopenia.

Original languageEnglish
Pages (from-to)277-281
Number of pages5
JournalPharmacological Research
Volume33
Issue number4-5
DOIs
Publication statusPublished - Apr 1996

Fingerprint

ketoprofen lysine
Metabolic Bone Diseases
Immobilization
Bone Density
Salts
Bone and Bones
Anti-Inflammatory Agents
Propionates
Prostaglandin-Endoperoxide Synthases
Bone Resorption
Osteogenesis
Osteoporosis
Tail
Spine

Keywords

  • Bone metabolism
  • Immobilization
  • Ketoprofen lysine salt
  • Osteopenia

ASJC Scopus subject areas

  • Pharmacology

Cite this

Ketoprofen lysine salt inhibits disuse-induced osteopenia in a new non-traumatic immobilization model in the rat. / Fiorentino, S.; Melillo, G.; Fedele, G.; Clavenna, G.; D'Agostino, C.; Mainetti, E.; Caselli, G. F.

In: Pharmacological Research, Vol. 33, No. 4-5, 04.1996, p. 277-281.

Research output: Contribution to journalArticle

Fiorentino, S. ; Melillo, G. ; Fedele, G. ; Clavenna, G. ; D'Agostino, C. ; Mainetti, E. ; Caselli, G. F. / Ketoprofen lysine salt inhibits disuse-induced osteopenia in a new non-traumatic immobilization model in the rat. In: Pharmacological Research. 1996 ; Vol. 33, No. 4-5. pp. 277-281.
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