Ketoprofen penetration into suction skin blister fluid: A comparison of two topical formulations of ketoprofen lysine

E. Perucca, E. Concia, M. Cruciani

Research output: Contribution to journalArticlepeer-review

Abstract

The transepidermal absorption of two topical formulations of ketoprolen lysine (foam and gel) was studied in 16 healthy male individuals in a comparative crossover randomized trial. The suction skin blister technique was used as a model to assess drug penetration into a liquid comparable to the interstitial fluid. Ketoprofen was rapidly absorbed across the skin blister wall, and peak concentrations in blister fluid were attained within 15 minutes in the majority of patients. A significantly higher peak concentration (P

Original languageEnglish
Pages (from-to)86-94
Number of pages9
JournalAdvances in Therapy
Volume10
Issue number2
Publication statusPublished - 1993

Keywords

  • Foam
  • Interstitial fluid
  • Ketoprofen lysine
  • Suction skin blister
  • Transepidermalabsorption

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Ketoprofen penetration into suction skin blister fluid: A comparison of two topical formulations of ketoprofen lysine'. Together they form a unique fingerprint.

Cite this