Ketotifen-induced nocturnal bruxism

Domenico Italiano, Placido Bramanti, David Militi, Stefania Mondello, Rocco Salvatore Calabro

Research output: Contribution to journalArticlepeer-review


Nocturnal bruxism is a common oromandibular movement disorder highly prevalent in children, but its pathophysiological mechanism has not been fully explained. Iatrogenic sleep bruxism has been described following treatment with several psychotropic medications. However, no case of antihistamine-induced bruxism has been reported to date. Herein, we describe a 4-year-old child who experienced nocturnal bruxism during treatment for bronchospasm and rhinitis with the antihistamine ketotifen. Drug rechallenge was also performed. Conclusion: The present case adds useful information to our knowledge of bruxism. Complex and poorly understood interactions between multiple central nervous system neurotransmitters, such as histamine, serotonin, and dopamine, are involved.

Original languageEnglish
Pages (from-to)1585-1586
Number of pages2
JournalEuropean Journal of Pediatrics
Issue number12
Publication statusPublished - Dec 1 2014


  • Antihistamine
  • Bruxism
  • Dopamine
  • Ketotifen
  • Serotonin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)


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