Ketotifen-induced nocturnal bruxism

Domenico Italiano, Placido Bramanti, David Militi, Stefania Mondello, Rocco Salvatore Calabro

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Nocturnal bruxism is a common oromandibular movement disorder highly prevalent in children, but its pathophysiological mechanism has not been fully explained. Iatrogenic sleep bruxism has been described following treatment with several psychotropic medications. However, no case of antihistamine-induced bruxism has been reported to date. Herein, we describe a 4-year-old child who experienced nocturnal bruxism during treatment for bronchospasm and rhinitis with the antihistamine ketotifen. Drug rechallenge was also performed. Conclusion: The present case adds useful information to our knowledge of bruxism. Complex and poorly understood interactions between multiple central nervous system neurotransmitters, such as histamine, serotonin, and dopamine, are involved.

Original languageEnglish
Pages (from-to)1585-1586
Number of pages2
JournalEuropean Journal of Pediatrics
Volume173
Issue number12
DOIs
Publication statusPublished - Dec 1 2014

Fingerprint

Sleep Bruxism
Ketotifen
Bruxism
Histamine Antagonists
Bronchial Spasm
Movement Disorders
Rhinitis
Histamine
Neurotransmitter Agents
Dopamine
Serotonin
Central Nervous System
Therapeutics
Pharmaceutical Preparations

Keywords

  • Antihistamine
  • Bruxism
  • Dopamine
  • Ketotifen
  • Serotonin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

Cite this

Ketotifen-induced nocturnal bruxism. / Italiano, Domenico; Bramanti, Placido; Militi, David; Mondello, Stefania; Calabro, Rocco Salvatore.

In: European Journal of Pediatrics, Vol. 173, No. 12, 01.12.2014, p. 1585-1586.

Research output: Contribution to journalArticle

Italiano, Domenico ; Bramanti, Placido ; Militi, David ; Mondello, Stefania ; Calabro, Rocco Salvatore. / Ketotifen-induced nocturnal bruxism. In: European Journal of Pediatrics. 2014 ; Vol. 173, No. 12. pp. 1585-1586.
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