Sixteen children, 7 boys and 9 girls, mean age 4.6 ± 0.9 years, with severe atopic dermatitis that did not respond to diet therapy were treated for 12 weeks with ketotifen. Changes in subjective symptoms were evaluated from diary charts and in objective symptoms from anthropographic charts. Drug consumption was also recorded, as was dietary treatment before (2 weeks), during and after (2 weeks) treatment. Standard laboratory tests were done before and after treatment, side effects were also recorded, both of these for evaluation of tolerance. Treatment effectively decreased both subjective and objective symptoms. Improvement was statistically significant by the second month of treatment, and drug consumption was less than in the pretreatment period. No side effects were recorded and the laboratory tests indicated no significant changes. The authors conclude that ketotifen can be used as a drug to treat atopic dermatitis.
|Number of pages||11|
|Journal||Current Therapeutic Research|
|Publication status||Published - 1985|
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