Key role of SMN/SYNCRIP and RNA-Motif 7 in spinal muscular atrophy: RNA-Seq and motif analysis of human motor neurons

F. Rizzo, M. Nizzardo, S. Vashisht, E. Molteni, V. Melzi, M. Taiana, S. Salani, P. Santonicola, E. Di Schiavi, M. Bucchia, A. Bordoni, I. Faravelli, N. Bresolin, G.P. Comi, U. Pozzoli, S. Corti

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)276-294
Number of pages19
JournalBrain
Volume142
Issue number2
DOIs
Publication statusPublished - 2019

Keywords

  • motor neurons
  • NRXN2
  • RNA sequencing
  • SMN1
  • SYNCRIP
  • bovine serum albumin
  • brain derived neurotrophic factor
  • cellular retinoic acid binding protein 1
  • chondrolectin
  • heat shock protein
  • heterogeneous nuclear ribonucleoprotein c like 1
  • heterogeneous nuclear ribonucleoprotein group C
  • insulin receptor substrate
  • muscle blind like protein 1
  • neurexin
  • neurexin 2
  • neurite promoting factor
  • potassium channel
  • potassium channel Kv1.3
  • protein
  • proteinase K
  • proteolipid protein
  • proteolipid protein 1
  • retinoic acid binding protein
  • RNA
  • RNA binding motif protein 47
  • RNA binding protein
  • RNA methyltransferase
  • RNA motif 7
  • somatomedin C
  • stathmin
  • stathmin 2
  • survival motor neuron protein
  • synaptotagmin
  • syncrip protein
  • unclassified drug
  • alternative RNA splicing
  • animal experiment
  • animal model
  • Article
  • axon guidance
  • Caenorhabditis elegans
  • cell differentiation
  • cell survival
  • controlled study
  • gene expression
  • gene overexpression
  • human
  • human cell
  • induced pluripotent stem cell
  • motoneuron
  • mouse
  • nonhuman
  • priority journal
  • protein function
  • RNA sequence
  • RNA splicing
  • RNA-binding domain
  • spinal muscular atrophy
  • upregulation

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