KFLC Index utility in multiple sclerosis diagnosis: Further confirmation

M. Pieri, M. Storto, S. Pignalosa, R. Zenobi, F. Buttari, S. Bernardini, D. Centonze, M. Dessi

Research output: Contribution to journalArticlepeer-review


The Multiple Sclerosis (MS) diagnosis is based on dissemination of focal lesions in time and space. The free light chains (FLCs) determination might be a sensitive alternative to oligoclonal bands assay. The study aim was to redefine sensitivity, specificity of the kFLC Index cut-off. We analyzed serum and cerebrospinal fluid of 176 patients, with different neurological disorders. We obtained a cut off of 12,3 for kFLC Index with a sensitivity and specificity of 93% and 100% respectively. Our data confirm that the kFLC Index is a valid tool in the diagnosis of MS.

Original languageEnglish
Pages (from-to)31-33
Number of pages3
JournalJournal of Neuroimmunology
Publication statusPublished - Aug 15 2017


  • Cerebrospinal fluid
  • Free light chain
  • kFLC Index
  • Multiple sclerosis
  • Nephelometric assay

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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