Ki-67 immunostaining in 322 primary breast cancers: Associations with clinical and pathological variables and prognosis

Annamaria Molino, Rocco Micciolo, Monica Turazza, Franco Bonetti, Quirino Piubello, Andrea Bonetti, Rolando Nortilli, Giuseppe Pelosi, Gian Luigi Cetto

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Cell-proliferation markers are very important in the clinical management of cancer patients, and the identification of Ki-67 (a monoclonal antibody that recognizes proliferating cells) can make it easier to define the level of proliferative activity. This study investigated the associations between the Ki-67 levels measured by means of immunohistochemistry, and other clinical and pathological variables and prognosis in 322 breast-cancer patients. A significant association was found (p <0.001) between Ki-67 values and tumor size, nodal status, estrogen and progesterone receptor status; multivariate analysis showed that Ki-67 levels were associated with disease-free and overall survival, thus confirming that it is an independent prognostic variable. Various statistical approaches were used in an attempt to establish the best cut-off point for dividing patients into groups at high or low risk of relapse but, in this series, we could find no evidence leading to a single 'best' cut-off point. We conclude that the quantitative level of Ki-67 could be used as a prognostic factor in breast-cancer patients.

Original languageEnglish
Pages (from-to)433-437
Number of pages5
JournalInternational Journal of Cancer
Volume74
Issue number4
DOIs
Publication statusPublished - 1997

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Breast Neoplasms
Progesterone Receptors
Estrogen Receptors
Disease-Free Survival
Neoplasms
Multivariate Analysis
Immunohistochemistry
Monoclonal Antibodies
Cell Proliferation
Recurrence

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Ki-67 immunostaining in 322 primary breast cancers : Associations with clinical and pathological variables and prognosis. / Molino, Annamaria; Micciolo, Rocco; Turazza, Monica; Bonetti, Franco; Piubello, Quirino; Bonetti, Andrea; Nortilli, Rolando; Pelosi, Giuseppe; Cetto, Gian Luigi.

In: International Journal of Cancer, Vol. 74, No. 4, 1997, p. 433-437.

Research output: Contribution to journalArticle

Molino, Annamaria ; Micciolo, Rocco ; Turazza, Monica ; Bonetti, Franco ; Piubello, Quirino ; Bonetti, Andrea ; Nortilli, Rolando ; Pelosi, Giuseppe ; Cetto, Gian Luigi. / Ki-67 immunostaining in 322 primary breast cancers : Associations with clinical and pathological variables and prognosis. In: International Journal of Cancer. 1997 ; Vol. 74, No. 4. pp. 433-437.
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AU - Turazza, Monica

AU - Bonetti, Franco

AU - Piubello, Quirino

AU - Bonetti, Andrea

AU - Nortilli, Rolando

AU - Pelosi, Giuseppe

AU - Cetto, Gian Luigi

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