Abstract
Original language | English |
---|---|
Pages (from-to) | 583-593 |
Number of pages | 11 |
Journal | Endocrine-Related Cancer |
Volume | 25 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2018 |
Keywords
- Ki67
- MANEC
- NEC
- Prognosis
- aldehyde dehydrogenase
- antineoplastic agent
- B Raf kinase
- beta catenin
- K ras protein
- Ki 67 antigen
- mismatch repair protein
- protein bcl 2
- protein p16
- protein p53
- stem cell factor receptor
- adult
- aged
- Article
- cancer diagnosis
- cancer localization
- cancer mortality
- cancer prognosis
- cancer risk
- cancer staging
- cancer survival
- cell proliferation
- clinical feature
- controlled study
- female
- human
- immunohistochemistry
- immunophenotyping
- major clinical study
- male
- mixed adenoneuroendocrine carcinoma
- multicenter study
- neoadjuvant chemotherapy
- overall survival
- retrospective study
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Ki67 proliferative index of the neuroendocrine component drives MANEC prognosis. / Milione, M.; Maisonneuve, P.; Pellegrinelli, A.; Grillo, F.; Albarello, L.; Spaggiari, P.; Vanoli, A.; Tagliabue, G.; Pisa, E.; Messerini, L.; Centonze, G.; Inzani, F.; Scarpa, A.; Papotti, M.; Volante, M.; Sessa, F.; Fazio, N.; Pruneri, G.; Rindi, G.; Solcia, E.; Rosa, S.L.; Capella, C.
In: Endocrine-Related Cancer, Vol. 25, No. 5, 2018, p. 583-593.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Ki67 proliferative index of the neuroendocrine component drives MANEC prognosis
AU - Milione, M.
AU - Maisonneuve, P.
AU - Pellegrinelli, A.
AU - Grillo, F.
AU - Albarello, L.
AU - Spaggiari, P.
AU - Vanoli, A.
AU - Tagliabue, G.
AU - Pisa, E.
AU - Messerini, L.
AU - Centonze, G.
AU - Inzani, F.
AU - Scarpa, A.
AU - Papotti, M.
AU - Volante, M.
AU - Sessa, F.
AU - Fazio, N.
AU - Pruneri, G.
AU - Rindi, G.
AU - Solcia, E.
AU - Rosa, S.L.
AU - Capella, C.
N1 - Cited By :5 Export Date: 5 February 2019 CODEN: ERCAE Correspondence Address: Milione, M.; 1st Pathology Division, Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei TumoriItaly; email: massimo.milione@istitutotumori.mi.it Chemicals/CAS: aldehyde dehydrogenase, 37353-37-0, 9028-86-8; protein bcl 2, 219306-68-0 Funding details: Università degli Studi di Pavia Funding details: Fondazione IRCCS Policlinico San Matteo Funding details: Associazione Italiana per la Ricerca sul Cancro, AIRC Funding details: Associazione Italiana per la Ricerca sul Cancro, AIRC, IG 2013 14696 Funding text 1: Aldo Scarpa is supported by AIRC 5 × 1000 n. 18182. Guido Rindi is supported by internal university grants (Università Cattolica line D.1 2015-R412500333 and D.1/2016-R412500403) and by the Associazione Italiana Ricerca sul Cancro – AIRC IG 2013 14696. Institutional support by: Fondazione IRCCS Istituto Nazionale Tumori Milano, Italy; European Institute of Oncology (IEO), Milan, Italy; Fondazione IRCCS Policlinico San Matteo and Department of Molecular Medicine, University of Pavia, Pavia, Italy; IRCCS San Raffaele Scientific Institute, Milan, Italy; Cancer Center Humanitas, Milan, Italy; this research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector. 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PY - 2018
Y1 - 2018
N2 - Mixed adenoneuroendocrine carcinomas (MANECs) are composed of a poorly differentiated neuroendocrine carcinoma (NEC) and a non-neuroendocrine (non-NEC) neoplastic epithelial component, each representing at least 30% of the tumor. At present, prognostic factors for MANECs remain largely unexplored. We investigated the clinical-pathologic features of a large multicenter series of digestive system MANECs. Surgical specimens of 200 MANEC candidates were centrally reviewed; diagnosis was confirmed in 160 cases. While morphology, proliferation (mitotic count (MC), Ki67 index) and immunophenotype (p53, SSTR2a, beta-Catenin, Bcl-2, p16, Rb1, ALDH, mismatch repair proteins and CD117) were investigated separately in both components, genomic (TP53, KRAS, BRAF) alterations were searched for on the entire tumor. Data were correlated with overall survival (OS). MANEC sites were: 92 colorectal, 44 gastroesophageal and 24 pancreatobiliary. Median OS was 13.2 months. After adjustment for primary site, Ki67 index of the NEC component (but not of the non-NEC component) was the most powerful prognostic marker. At multivariable analysis, patients with Ki67≥55% had an 8-fold risk of death (hazard ratio (HR) 7.83; 95% confidence interval (CI) 4.17–14.7; P
AB - Mixed adenoneuroendocrine carcinomas (MANECs) are composed of a poorly differentiated neuroendocrine carcinoma (NEC) and a non-neuroendocrine (non-NEC) neoplastic epithelial component, each representing at least 30% of the tumor. At present, prognostic factors for MANECs remain largely unexplored. We investigated the clinical-pathologic features of a large multicenter series of digestive system MANECs. Surgical specimens of 200 MANEC candidates were centrally reviewed; diagnosis was confirmed in 160 cases. While morphology, proliferation (mitotic count (MC), Ki67 index) and immunophenotype (p53, SSTR2a, beta-Catenin, Bcl-2, p16, Rb1, ALDH, mismatch repair proteins and CD117) were investigated separately in both components, genomic (TP53, KRAS, BRAF) alterations were searched for on the entire tumor. Data were correlated with overall survival (OS). MANEC sites were: 92 colorectal, 44 gastroesophageal and 24 pancreatobiliary. Median OS was 13.2 months. After adjustment for primary site, Ki67 index of the NEC component (but not of the non-NEC component) was the most powerful prognostic marker. At multivariable analysis, patients with Ki67≥55% had an 8-fold risk of death (hazard ratio (HR) 7.83; 95% confidence interval (CI) 4.17–14.7; P
KW - Ki67
KW - MANEC
KW - NEC
KW - Prognosis
KW - aldehyde dehydrogenase
KW - antineoplastic agent
KW - B Raf kinase
KW - beta catenin
KW - K ras protein
KW - Ki 67 antigen
KW - mismatch repair protein
KW - protein bcl 2
KW - protein p16
KW - protein p53
KW - stem cell factor receptor
KW - adult
KW - aged
KW - Article
KW - cancer diagnosis
KW - cancer localization
KW - cancer mortality
KW - cancer prognosis
KW - cancer risk
KW - cancer staging
KW - cancer survival
KW - cell proliferation
KW - clinical feature
KW - controlled study
KW - female
KW - human
KW - immunohistochemistry
KW - immunophenotyping
KW - major clinical study
KW - male
KW - mixed adenoneuroendocrine carcinoma
KW - multicenter study
KW - neoadjuvant chemotherapy
KW - overall survival
KW - retrospective study
U2 - 10.1530/ERC-17-0557
DO - 10.1530/ERC-17-0557
M3 - Article
VL - 25
SP - 583
EP - 593
JO - Endocrine-Related Cancer
JF - Endocrine-Related Cancer
SN - 1351-0088
IS - 5
ER -