TY - JOUR
T1 - KIBRA T allele influences memory performance and progression of cognitive decline
T2 - a 7-year follow-up study in subjective cognitive decline and mild cognitive impairment
AU - Mazzeo, Salvatore
AU - Bessi, Valentina
AU - Padiglioni, Sonia
AU - Bagnoli, Silvia
AU - Bracco, Laura
AU - Sorbi, Sandro
AU - Nacmias, Benedetta
PY - 2019/4/11
Y1 - 2019/4/11
N2 - KIBRA is a signal transducer protein, mainly expressed in the kidney and brain. A single-nucleotide polymorphism (SNP rs17070145, T → C exchange) has been linked to different cognitive function. In 2008, we studied 70 subjects who complained of subjective cognitive decline (SCD) and found that CT/TT carriers performed worse than CC carriers on a long-term memory test. We followed up the 70 SCD subjects and also 31 subjects affected by mild cognitive impairment (MCI) for a mean follow-up time of 7 years, during which 16 SCD subjects progressed to MCI and 14 MCI subjects progressed to Alzheimer’s disease (AD). Carrying the T allele was associated with MCI and with a two times-higher risk of developing MCI than CC carriers. In the SCD sample, CT/TT carriers showed a greater worsening on Rivermead Behavioral Memory Test (RBMT) compared to CC carriers. In the MCI sample, CT/TT carriers performed worse than CC carriers on RBMT. There is a lack of consensus on the effect of KIBRA gene variants on cognitive performances in episodic memory and on the risk of AD. Our results confirm a role of T allele on progression of cognitive decline.
AB - KIBRA is a signal transducer protein, mainly expressed in the kidney and brain. A single-nucleotide polymorphism (SNP rs17070145, T → C exchange) has been linked to different cognitive function. In 2008, we studied 70 subjects who complained of subjective cognitive decline (SCD) and found that CT/TT carriers performed worse than CC carriers on a long-term memory test. We followed up the 70 SCD subjects and also 31 subjects affected by mild cognitive impairment (MCI) for a mean follow-up time of 7 years, during which 16 SCD subjects progressed to MCI and 14 MCI subjects progressed to Alzheimer’s disease (AD). Carrying the T allele was associated with MCI and with a two times-higher risk of developing MCI than CC carriers. In the SCD sample, CT/TT carriers showed a greater worsening on Rivermead Behavioral Memory Test (RBMT) compared to CC carriers. In the MCI sample, CT/TT carriers performed worse than CC carriers on RBMT. There is a lack of consensus on the effect of KIBRA gene variants on cognitive performances in episodic memory and on the risk of AD. Our results confirm a role of T allele on progression of cognitive decline.
KW - Alzheimer’s disease
KW - ApoE
KW - KIBRA
KW - Mild cognitive impairment
KW - Neuropsychology
KW - Subjective cognitive decline
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UR - http://www.scopus.com/inward/citedby.url?scp=85064492052&partnerID=8YFLogxK
U2 - 10.1007/s10072-019-03866-8
DO - 10.1007/s10072-019-03866-8
M3 - Article
C2 - 30953258
AN - SCOPUS:85064492052
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
ER -