Terapie onco-ematologiche e danno renale: dalla sindrome da lisi tumorale alla nefropatia post-trapianto di midollo.

Translated title of the contribution: [Kidney damage caused by treatment for hematological malignancies: from tumor lysis syndrome to post-transplant kidney failure].

Sonia Pasquali, Lucio Manenti, Mariacristina Gregorini, Alfredo Stefani, Roberto Rustichelli

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In the wide spectrum of therapies for hematological malignancies, hematopoietic stem cell transplantation, whether autologous or allogeneic, is a common procedure. In addition to other transplant-related organ toxicities, renal failure is a common complication following transplantation. This paper discusses the incidence, timing, etiologies, risk factors and prognosis of renal failure associated with three commonly used transplantation procedures: myeloablative autologous, myeloablative allogeneic, and non-myeloablative allogeneic transplantation. The epidemiology and prognosis of renal failure are different after these three procedures. Severe renal failure occurs with all three varieties, but the frequency increases from myeloablative autologous to non-myeloablative allogeneic to myeloablative allogeneic. In all three types of transplantation, the mortality is clearly associated with the severity of renal injury, and it is greater than 80% when dialysis is required. Strategies to improve renal failure following transplantation may have a beneficial impact on these patients. Reduction of acute renal failure will likely reduce the severity of non-renal organ dysfunction, the incidence and severity of chronic kidney disease, and the mortality.

Original languageItalian
JournalGiornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia
Volume27 Suppl 50
Publication statusPublished - Sep 2010

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Tumor Lysis Syndrome
Hematologic Neoplasms
Renal Insufficiency
Transplants
Kidney
Transplantation
Therapeutics
Mortality
Hematopoietic Stem Cell Transplantation
Incidence
Homologous Transplantation
Chronic Renal Insufficiency
Acute Kidney Injury
Dialysis
Epidemiology
Wounds and Injuries

ASJC Scopus subject areas

  • Nephrology

Cite this

Terapie onco-ematologiche e danno renale : dalla sindrome da lisi tumorale alla nefropatia post-trapianto di midollo. / Pasquali, Sonia; Manenti, Lucio; Gregorini, Mariacristina; Stefani, Alfredo; Rustichelli, Roberto.

In: Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia, Vol. 27 Suppl 50, 09.2010.

Research output: Contribution to journalArticle

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