Kidney-detrimental factors and estimated glomerular filtration rate in preterm newborns: The role of nutrition

Alice Monzani, Ilaria Crespi, Giulia Genoni, Alberto Edefonti, Giovanni Montini, Giorgio Bellomo, Federica Ferrero, Simonetta Bellone, Flavia Prodam

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Kidney function in preterm newborns may be impaired by many factors. Methods: 71 newborns with gestational age (GA) < 32 weeks were enrolled. Serum creatinine (sCr), cystatin C (CysC), beta-trace protein (BTP) and urea were measured at T0 (3rd day of life) and T36 (GA 36 weeks), and estimated glomerular filtration rate (eGFR) was calculated according to different formulas at T36. Pre-natal and post-natal kidney injury risk scores were calculated. Results: Newborns with GA ≤ 28 weeks had higher sCr at T0, and lower sCr, BTP and higher urea levels at T36 (p = 0.007, p = 0.005 and p = 0.029, respectively). eGFR values were not different according to GA when calculated by the formulas using only CysC, but were higher in subjects with GA ≤ 28 weeks according to the other formulas. The post-natal score was positively correlated with eGFR according to sCr-based formulas, but the correlations did not persist when adjusted for urea levels and GA. Conclusions: CysC-based eGFR values are not influenced by GA. Post-natal score shows a direct correlation with eGFR according to sCr-based formulas, not persisting after adjustment for GA and urea levels, implying the importance of the nutritional status, since more premature subjects receive a more aggressive nutritional regimen, testified by higher urea levels.

Original languageEnglish
Article number651
JournalNutrients
Volume12
Issue number3
DOIs
Publication statusPublished - Mar 2020

Keywords

  • Beta-trace protein
  • Chronic kidney disease
  • Cystatin C
  • Kidney function
  • Parenteral nutrition
  • Preterm newborn

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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